Results 201 to 210 of about 63,776 (234)
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice
American Journal of Physiology-Cell Physiology, 1992 The adipocyte membrane G protein pattern, beta-adrenergic receptor activity, and adenylyl cyclase were determined in adipocyte membranes of the db/db mouse, a mutant that is a model of diabetes preceded by hyperinsulinemia, hyperglycemia, and extreme obesity. These studies were undertaken to determine whether the alterations already noted in the ob/ob
Nicole Bégin‐Heick
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Biochemistry, 1989 The G-protein GS couples hormone-activated receptors with adenylyl cyclase and stimulates increased cyclic AMP synthesis. Transient expression in COS-1 cells of cDNAs coding for the GS alpha-subunit (alpha S) or alpha S cDNAs having single amino acid mutations Gly49----Val or Gly225----Thr elevated cyclic AMP levels, resulting in the activation of ...
Chee Wai Woon +3 more
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Pathology - Research and Practice, 1991 Very recently a subset of human GH-secreting pituitary adenomas carrying a somatic mutation in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) was identified. In all these tumors (Group 2; about 30% of all the GH secreting tumors studied) the alpha s cDNAs contained mutations; in 8 tumors mutations replaced Arginine 201
A. Spada +5 more
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Biochemistry, 1991 The selective regulation of Gs (long and short forms), Gi's (1, 2, and 3), and Go by the beta-adrenergic receptor was assessed quantitatively after coreconstitution of purified receptor, purified G-protein beta gamma subunits, and individual recombinant G-protein alpha subunits that were expressed in and purified from Escherichia coli.
Ronald C. Rubenstein +2 more
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Analysis of mutations in the Gs protein α subunit gene in human leukaemia
Leukemia Research, 1992Mutations at codons 201 and 227 that cause oncogenic activation of the gene encoding the Gs alpha subunit protein occur in a subset of human solid tumours. To determine whether such oncogenic mutations occur in leukaemia we have analysed DNA from leukaemic cells from 59 patients representing a spectrum of acute and chronic leukaemia types by direct ...
John D. Norton, Bartrum W. Baker
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GTPase-inhibiting mutations in the alpha subunit of Gs.
Advances in second messenger and phosphoprotein research, 1990 Susan B. Masters +2 more
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Nature, 1992
Fully-differentiated mouse 3T3-L1 fibroblasts accumulate large amounts of lipid at 7-10 days after induction by insulin or by dexamethasone and a methyl xanthine. G proteins mediate transmembrane signalling from a diverse group of cell-surface receptors to effector units that include phospholipase C, adenylyl cyclase and ion channels.
Craig C. Malbon +2 more
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Fully-differentiated mouse 3T3-L1 fibroblasts accumulate large amounts of lipid at 7-10 days after induction by insulin or by dexamethasone and a methyl xanthine. G proteins mediate transmembrane signalling from a diverse group of cell-surface receptors to effector units that include phospholipase C, adenylyl cyclase and ion channels.
Craig C. Malbon +2 more
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Trimeric G Protein α Subunits of the Gs and Gi Families Localized at the Golgi Membrane
Biochemical and Biophysical Research Communications, 1995The occurrence of individual G proteins within Golgi membranes from liver and from adrenal medulla were analyzed by Western blotting. Two splice variants of G alpha s and also G alpha i-3 were found in both tissues. Additionally, G alpha i-2, its 43-kDa splice variant and G alpha o were strongly labeled in Golgi of adrenal medulla.
P. Westermann, E. Ehmsen, O. Maier
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[9] Preparation of activated α subunits of Gs and GiS: From erythrocyte to activated subunit
1994Publisher Summary This chapter discusses procedure for the purification of Gs and Gi (mixture of Gi2 and Gi3) from human erythrocytes, followed by an example of separate purification of Gi2 from Gi3. A general protocol for activation and isolation of the activated α subunits of the three G proteins is given. The activation and isolation procedure are
Lutz Birnbaumer +3 more
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