Results 231 to 240 of about 167,144 (276)

An unusual presentation of McCune-Albright syndrome confirmed by an activating mutation of the Gs alpha-subunit from a bone lesion

The Journal of Clinical Endocrinology & Metabolism, 1994
The McCune-Albright syndrome (MAS) is characterized clinically by polyostotic fibrous dysplasia, café-au-lait skin lesions, sexual precocity, and various other endocrinopathies. Recent investigations suggest an etiological role for embryonic somatic missense mutations that predict the substitution of a His or Cys for Arg at amino acid 201 of the Gs ...
Carl D. Malchoff
semanticscholar   +6 more sources

Mutation of glycine 49 to valine in the .alpha. subunit of Gs results in the constitutive elevation of cyclic AMP synthesis

Biochemistry, 1989
The G-protein GS couples hormone-activated receptors with adenylyl cyclase and stimulates increased cyclic AMP synthesis. Transient expression in COS-1 cells of cDNAs coding for the GS alpha-subunit (alpha S) or alpha S cDNAs having single amino acid mutations Gly49----Val or Gly225----Thr elevated cyclic AMP levels, resulting in the activation of ...
Chee Wai Woon, Lynn E. Heasley, Shoji Osawa, Gary L. Johnson   +3 more
semanticscholar   +6 more sources

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

American Journal of Physiology-Heart and Circulatory Physiology, 1988
Specific guanine nucleotide-binding proteins (G proteins) couple receptors to calcium channels indirectly via cytoplasmic agents such as protein kinases (Birnbaumer et al., Kidney Int. 32: 514-537, 1987). Direct coupling between the stimulatory G protein from adenylyl cyclase (Gs) and calcium channels has been shown recently in inside-out cell-free ...
Yutaka Imoto, Atsuko Yatani, J P Reeves, Juan Codina, Lutz Birnbaumer, Arthur Brown   +5 more
openalex   +4 more sources

Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).

Endocrinology, 2009
GNAS gives rise to multiple imprinted gene products, including the alpha-subunit of the stimulatory G protein (Gs(alpha)) and its variant XL(alpha)s. Based on genomic sequence, the translation of XL(alpha)s begins from the middle of a long open reading frame, suggesting the existence of an N-terminally extended variant termed extralarge XLalphas (XXL ...
Cumhur, Aydin, Nurgul, Aytan, Mathew J, Mahon, Hesham A W, Tawfeek, Neil W, Kowall, Alpaslan, Dedeoglu, Murat, Bastepe   +6 more
openaire   +3 more sources

Effect of activating and inactivating mutations of GS-and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes

Journal of Cellular Biochemistry, 1997
Previous investigations have demonstrated that both Gs- and the Gi-family of GTP-binding proteins are implicated in differentiation of the 3T3-L1 preadipocyte. In order to further analyze the role of Gs alpha vs. Gi2 alpha, which are both involved in adenylate cyclase modulation, we transfected undifferentiated 3T3-L1 cells with two sets of G-protein ...
Jan O. Gordeladze, Kjerstin Elisabeth Høvik, John J. Merendino, Sylvie Hermouet, J. Silvio Gutkind, Domenico Accili   +5 more
openalex   +4 more sources

Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice

American Journal of Physiology-Cell Physiology, 1992
The adipocyte membrane G protein pattern, beta-adrenergic receptor activity, and adenylyl cyclase were determined in adipocyte membranes of the db/db mouse, a mutant that is a model of diabetes preceded by hyperinsulinemia, hyperglycemia, and extreme obesity. These studies were undertaken to determine whether the alterations already noted in the ob/ob
Nicole Bégin‐Heick
openalex   +3 more sources

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Exclusion of close linkage of bipolar disorder to the Gs-α subunit gene in nine Australian pedigrees

Journal of Affective Disorders, 1994
Growing evidence suggests that guanine nucleotide binding proteins (G proteins) may be involved in both the pathogenesis and treatment of bipolar affective disorder. Both overactive G proteins and increased levels of the alpha subunit of the stimulatory form (Gs-alpha) have been demonstrated in peripheral leucocytes of manic patients while an increase ...
Christina Vivero, Lisa Selbie, F. Le, John Shine, Brent Waters, Peter R. Schofield, Philip B. Mitchell, Jennifer A. Donald   +7 more
openaire   +4 more sources

Mutations in the Alpha Subunit of the Stimulatory Regulatory Protein of Adenylyl Cyclase (Gs) in Human GH-Secreting Pituitary Adenomas

Pathology - Research and Practice, 1991
Very recently a subset of human GH-secreting pituitary adenomas carrying a somatic mutation in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) was identified. In all these tumors (Group 2; about 30% of all the GH secreting tumors studied) the alpha s cDNAs contained mutations; in 8 tumors mutations replaced Arginine 201
A. Spada, Maura Arosio, M. Bassetti, Lucia Vallar, Emilio Clementi, Nicoletta Bazzoni   +5 more
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[24] Detection of mutations and polymorphisms of Gsα subunit gene by denaturing gradient Gel electrophoresis

Methods in Enzymology, 1994
Publisher Summary The genomic structure of the α subunit of the guanine nucleotide-binding protein G s (G s α ) is composed of 13 exons and 12 introns spanning more than 20 kilobases (kb), whereas the transcribed message of the gene is approximately 1.9 kb in length. Denaturing gradient gel electrophoresis (DGGE) analysis detected several disease-
Lee S. Weinstein, Pablo V. Gejman
openaire   +4 more sources

[19] Assays for studying functional properties of in vitro translated Gsα subunit

Methods in Enzymology, 1994
Publisher Summary This chapter discusses different procedure designed to study the functional properties of mutated in vitro translated Gsα subunits. The relationship between the structure and function of a protein has been widely explored by in vitro mutagenesis of the cDNA encoding the protein and expression of the mutated protein in an eukaryotic ...
Y. Audigier
openaire   +4 more sources