Results 21 to 30 of about 71,714 (251)

Diurnal regulation of metabolism by Gs-alpha in hypothalamic QPLOT neurons.

PLoS ONE, 2023
Neurons in the hypothalamic preoptic area (POA) regulate multiple homeostatic processes, including thermoregulation and sleep, by sensing afferent input and modulating sympathetic nervous system output.
Kevin D Gaitonde, Mutahar Andrabi, Courtney A Burger, Shane P D'Souza, Shruti Vemaraju, Bala S C Koritala, David F Smith, Richard A Lang   +7 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

RECOMBINANT HUMAN LUTEINIZING HORMONE FOR THE TREATMENT OF INFERTILITY: THE GENERATION OF PRODUCER CELL LINES

Акушерство, гинекология и репродукция, 2017
The aim of the study was to obtain the cell line secreting the maximum amounts of the human luteinizing hormone (LH) heterodimer without significant amounts of free LH alpha-subunit.Materials and methods.
N. A. Orlova, S. V. Kovnir, Yu. A. Khodak, M. A. Polzikov, I. I. Vorobiev   +4 more
doaj   +1 more source

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII [PDF]

, 2008
Regulation of intracellular cyclic adenosine 3’, 5’-monophosphate (cAMP) by multiple pathways enables differential function of this ubiquitous second messenger in a context dependent manner.
Collins, Julie, Davis, Richard, Fraser, Iain D., Jiang, Lily I., Sternweis, Paul C.   +4 more
core   +2 more sources

Radioiodine treatment in McCune-Albright syndrome with hyperthyroidism

Indian Journal of Endocrinology and Metabolism, 2012
McCune-Albright syndrome (MAS) is a sporadic disease characterized by polyostotic fibrous dysplasia, "café-au-lait" spots and hyperfunctional endocrinopathies.
Dhritiman Chakraborty, Bhagwant Rai Mittal, Raghava Kashyap, Kuruva Manohar, Anish Bhattacharya, Anil Bhansali   +5 more
doaj   +1 more source

A G protein-coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia.

PLoS Biology, 2020
The reproductive hormones that trigger oocyte meiotic maturation and release from the ovary vary greatly between animal species. Identification of receptors for these maturation-inducing hormones (MIHs) and understanding how they initiate the largely ...
Gonzalo Quiroga Artigas, Pascal Lapébie, Lucas Leclère, Philipp Bauknecht, Julie Uveira, Sandra Chevalier, Gáspár Jékely, Tsuyoshi Momose, Evelyn Houliston   +8 more
doaj   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.

PLoS ONE, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Sarah Auburn, Andrew E Fry, Taane G Clark, Susana Campino, Mahamadou Diakite, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Malcolm E Molyneux, Terrie E Taylor, Kasturi Haldar, Kirk A Rockett, Dominic P Kwiatkowski   +14 more
doaj   +1 more source

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian, Caro, Lydia N, Dror, Ron O, Ernst, Oliver P, Hollingsworth, Scott A, Hubbell, Wayne L, Latorraca, Naomi R, Van Eps, Ned   +7 more
core   +1 more source

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism, but not in suckling [PDF]

, 2012
The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been ...
Abramowitz J, Balthasar N, Bamshad M, Bartness TJ, Bastepe M, Bastepe M, Baxendale RW, Bunting M, Castrop H, Cattanach BM, Cattanach BM, Chen M, Chen M, Chen M, Chotalia M, Crawford JA, de Bovis B, de Paula FJ, Ducy P, Elefteriou F, Friedman JM, Fu L, Fukao M, Germain-Lee EL, Hayward BE, Holmes R, Ivanova E, Kawai M, Kaya AI, Kehlenbach RH, Kelly ML, Kelsey G, Klemke M, Klemke M, Kublaoui BM, Lam DD, Liu J, Maffei M, Moore T, Oswal A, Pasolli HA, Pasolli HA, Peters J, Peters J, Peters J, Plagge A, Plagge A, Sakamoto A, Sakamoto A, Schmidt-Nielsen K, Shin JY, Shrestha YB, Skinner JA, Sleutels F, Storck T, Weinstein LS, Weinstein LS, Williamson CM, Williamson CM, Williamson CM, Wroe SF, Xie T, Yadav VK, Youngstrom TG, Yu S, Yu S   +65 more
core   +1 more source