Results 61 to 70 of about 167,144 (276)

Review: Dystroglycan in the Nervous System [PDF]

open access: yes, 2007
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core   +2 more sources

Spin parity and broken symmetry in finite spin-1/2 chains with frustrated exchange: quantum transition from high to low spin [PDF]

open access: yesPhys. Rev. B 85, 144415 (2012), 2012
Exact diagonalization of finite spin-1/2 chains with periodic boundary conditions is applied to the ground state (gs) of chains with ferromagnetic (F) exchange $J_1 < 0$between first neighbors, antiferromagnetic (AF) exchange $J_2 = \alpha J_1 > 0$between second neighbors, and axial anisotropy $0 \le \Delta \le 1$. In zero field, the gs is in the $S_z =
arxiv   +1 more source

Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).

open access: yesBiochemical Journal, 1989
The effect of activation of the alpha-subunit(s) of the stimulatory guanine-nucleotide-binding protein, Gs, on levels of this polypeptide(s) associated with the plasma membrane of L6 skeletal myoblasts was ascertained.
G. Milligan, C. Unson, M. Wakelam
semanticscholar   +1 more source

Structure of A=7 iso-triplet $Λ$ hypernuclei studied with he four-body model [PDF]

open access: yesPhys.Rev.C80:054321,2009, 2009
The structure of the T=1 iso-triplet hypernuclei, $^7_{\Lambda}$He, $^7_{\Lambda}$Li and $^7_{\Lambda}$Be within the framework of an $\alpha +\Lambda +N+N$ four-body cluster model is studied. Interactions between the constituent subunits are determined so as to reproduce reasonably well the observed low-energy properties of the $\alpha N$, $\alpha ...
arxiv   +1 more source

Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes [PDF]

open access: yes, 1994
Xenopus oocytes were used to examine the coupling of the serotonin 1c (5HT1c) and thyrotropin-releasing hormone (TRH) receptors to both endogenous and heterologously expressed G protein alpha subunits.
Aragay, Anna M.   +4 more
core  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters

open access: yesAngewandte Chemie, EarlyView.
Benzamide‐directed iridium‐catalyzed branched selective and enantioselective C(sp2)‐H additions to minimally activated alkenes give tertiary and quaternary benzylic stereocenters under byproduct‐free conditions. The processes are enabled by a family of SPINOL‐based homochiral diphosphonite ligands.
Timothy P. Aldhous   +9 more
wiley   +2 more sources

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma [PDF]

open access: yes, 1992
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) consist of a nucleotide-binding alpha subunit and a high- affinity complex of beta and gamma subunits.
Gilman, Alfred G.   +3 more
core  

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

open access: yes, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco   +6 more
core   +3 more sources

Concurrent down-regulation of IP prostanoid receptors and the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma x glioma cells to prostanoid agonists. Quantification and functional implications.

open access: yesBiochemical Journal, 1992
Neuroblastoma x glioma hybrid NG108-15 cells express a high-affinity IP prostanoid receptor. Saturation binding analysis of this receptor, using [3H]prostaglandin E1 ([3H]PGE1) as ligand, indicated that it was present at some 1.5 pmol/mg of membrane ...
E. J. Adie   +3 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy