Results 81 to 90 of about 167,144 (276)

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Algorithms of maximum likelihood data clustering with applications

, 2002
We address the problem of data clustering by introducing an unsupervised, parameter free approach based on maximum likelihood principle. Starting from the observation that data sets belonging to the same cluster share a common information, we construct ...
Alter, Blatt, Domany, Eisen, Getz, Getz, Giada, Gopikrishnan, Hartigan, Kirkpatrick, Kullmann, Lauritzen, Lorenzo Giada, Mantegna, Matteo Marsili, Metropolis, Spellman, Tamayo   +17 more
core   +1 more source

Novel CTSA Variant Identified in a Thai Family With Late-Infantile Galactosialidosis. [PDF]

Ann Hum Genet
ABSTRACT Galactosialidosis (GS) is a rare lysosomal storage disease (LSD) with variable onset caused by a defect in protective protein/cathepsin A (PPCA) encoded by the CTSA gene. The late‐infantile onset is characterized by developmental delay, visceromegaly, coarse facies, and cherry‐red macula.
Ngiwsara L, Dhachpramuk D, Sawangareetrakul P, Vongphit S, Pacharn P, Svasti J, Vatanavicharn N.   +6 more
europepmc   +2 more sources

Strongly Enhanced Low Energy Alpha-Particle Decay in Heavy Actinide Nuclei and Long-Lived Superdeformed and Hyperdeformed Isomeric States [PDF]

Int.J.Mod.Phys.E10:209-236,2001, 2000
Relatively low energy and very enhanced alpha-particle groups have been observed in various actinide fractions produced via secondary reactions in a CERN W target which had been irradiated with 24-GeV protons. In particular, 5.14, 5.27 and 5.53 MeV alpha-particle groups with corresponding half-lives of 3.8(+ -)1.0 y, 625(+ -)84 d and 26(+ -)7 d, have ...
arxiv   +1 more source

Antiviral effects and mechanism of Qi pi pill against influenza viruses

Animal Models and Experimental Medicine, EarlyView.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang, Jing Gao, Meiyue Dong, Carolina Q. Sacramento, Ping Li, Xiangyu Lian, Lingyuan Fan, Lijun Rong, Ruikun Du, Jingzhen Tian, Qinghua Cui   +10 more
wiley   +1 more source

Precise Similarity of Many Human Proteins to Proteins of Prokarya [PDF]

, 2007
Proteins originated in early forms of life and have long survived, because they have always been required. Some recognizably similar proteins are found in all sequence comparisons between species, no matter how distant, including prokaryotes and ...
Roy Britten
core   +2 more sources

The Juxtamembrane, Cytosolic Region of the Epidermal Growth Factor Receptor Is Involved in Association with α-Subunit of Gs [PDF]

Journal of Biological Chemistry, 1997
Previously, we have demonstrated that epidermal growth factor (EGF) can stimulate adenylyl cyclase activity via activation of Gs in the heart. Moreover, we have recently shown that Gsalpha is phosphorylated by the EGF receptor protein tyrosine kinase and that the juxtamembrane region of the EGF receptor can stimulate Gs directly.
Klaus Scholich, Helen M. Poppleton, Zutang Chen, Paul J. Bertics, Tarun B. Patel, Hui Sun, David L. Fulgham, Jason Mullenix, Gregory J. Weipz   +8 more
openaire   +2 more sources

Isolation and characterization of the human Gs alpha gene.

Proceedings of the National Academy of Sciences of the United States of America, 1988
The gene for Gs alpha (the alpha subunit of the guanine nucleotide-binding protein Gs) was isolated from human genomic libraries using rat Gs alpha cDNA as a probe.
T. Kozasa, H. Itoh, T. Tsukamoto, Y. Kaziro   +3 more
semanticscholar   +1 more source

Sugar‐sensing swodkoreceptors and swodkocrine signaling

Animal Models and Experimental Medicine, EarlyView.
Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
wiley   +1 more source

Wolbachia causes cytoplasmic incompatibility but not male‐killing in a grain pest beetle

Molecular Ecology, Volume 31, Issue 24, Page 6570-6587, December 2022., 2022
Abstract The endosymbiotic Wolbachia is one of the most common intracellular bacteria known in arthropods and nematodes. Its ability for reproductive manipulation can cause unequal inheritance to male and female offspring, allowing the manipulator to spread, but potentially also impact the evolutionary dynamics of infected hosts.
Julian S. T. Kiefer, Gerrit Schmidt, Ronja Krüsemer, Martin Kaltenpoth, Tobias Engl   +4 more
wiley   +1 more source