Results 251 to 260 of about 18,138 (288)

Enterovirus 71 infection induces pyroptotic brain injury via synergistic activation of classical inflammasome and viral gasdermin D cleavage. [PDF]

J Virol
Liu T, Wang B, Li Y, Tian S, Gao X, Fan Y, Zhang X, Yang L, Wu R, Liu L.   +9 more
europepmc   +1 more source

RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis. [PDF]

Nat Commun
Ma M, Wang F, Cui P, Zhang Y, Ma H, He Y, Cheng Y, Huang J, Wang J, Wu X, Yang H, Zheng R, Ma H, Cai Q, Wang L, Ge B.   +15 more
europepmc   +1 more source

PANoptosis: a potential target of cardiomyopathy. [PDF]

Front Immunol
Sun M, Lu C, Wei J, Gao C, Dong D.
europepmc   +1 more source

Disulfiram Prevents Blood-Brain Barrier Disruption in Epileptic Mice by Inhibiting Astrocyte Pyroptosis to Improve Seizure Activity. [PDF]

Mol Neurobiol
Zhang M, Zhao L, Chen S, Huang W, Jin X, Xu H.   +5 more
europepmc   +1 more source

[<i>Morinda officinalis</i> polysaccharide delays osteoarthritis mouse chondrocyte degeneration by modulating the glycolysis-pyroptosis axis <i>via</i> targeting the lncRNA XIST]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Fu C, Chen R, Xu S, You J, Lin Q, Huang Y.   +5 more
europepmc   +1 more source

Influence of Pyroptosis Induced by NOD-Like Receptor Pyrin Domain-Containing 3 Inflammasomes on Viral Myocarditis in Children. [PDF]

Int J Gen Med
Huang H, Lou J, Chen W, Cheng X, Xing X, Huang S.   +5 more
europepmc   +1 more source

Pyroptosis-Mediator GSDMD in Plasma: A Promising Biomarker for Early Diagnosis of Type 2 Diabetes

Lijing Huo, Xuexin Liu, Nan Ding, Hairui Zhang, Shiyu Hou, Jintian He, Baohua Zhao   +6 more
openalex   +2 more sources

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis [PDF]

Cell, 2020
The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1 and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from GSDMD-C-terminal domain. How the caspases recognize GSDMD and its connection with caspase activation are unknown.
Zilin Li, Jingjin Ding
exaly   +3 more sources

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Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis

Cell Biology and Toxicology, 2021
Our group previously reported that hirudin ameliorated diabetic nephropathy (DN) in streptozotocin (STZ)-injected rats, but the mechanism remained largely unknown. Therefore, we further explored its possible mechanism. We subcutaneously injected 5 U hirudin into STZ-induced WT mice or Gasdermin D (Gsdmd)-/- (KO) mice daily for 12 weeks, respectively ...
Jiarui, Han, Zhenkui, Zuo, Xiujie, Shi, Yage, Zhang, Zining, Peng, Yufeng, Xing, Xinxin, Pang   +6 more
openaire   +2 more sources