Results 261 to 270 of about 18,138 (288)

GSDMD deficiency drives immunopathology in cutaneous leishmaniasis

The Journal of Immunology, 2022
Abstract Cutaneous leishmaniasis is a neglected tropical disease that results in severe, chronic lesions that are frequently resistant to parasite-directed therapy. Studies in patients and murine models indicate that NLRP-3 dependent IL-1β release is associated with more severe disease and treatment failure.
Christina K Go, James Grayczyk, Igor E Brodsky, Phillip A Scott   +3 more
openaire   +1 more source

Brain endothelial GSDMD activation mediates inflammatory BBB breakdown

Nature
The blood-brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2-4. However, the mechanisms of BBB disruption during infection and inflammatory conditions5,6 remain poorly defined.
Li Zhang, Lisa D J Schiffelers, Bin Zhou
exaly   +4 more sources

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages [PDF]

Nature Communications, 2021
AbstractCandida albicansis the most common cause of fungal sepsis. Inhibition of inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, inflammasome signaling appears to protect againstC. albicansinfection, so inflammasome inhibitors are not clinically useful for candidiasis. Here we show disruption of GSDMD, a known
Hiroto Kambara, Maikel Acosta-Zaldívar, Ting Bei   +2 more
exaly   +4 more sources

IRF2 transcriptionally induces GSDMD expression for pyroptosis

Science Signaling, 2019
Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.
Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O'Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit   +18 more
openaire   +2 more sources

Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens

Trends in Immunology, 2023
In a recent article, He et al. report that, in response to dietary protein antigens, mouse intestinal epithelial cells (IECs) accumulate a newfound 13-kDa N terminus of gasdermin D (GSDMD-N13), cleaved by caspase-3/7. Unlike the pyroptotic 30-kDa fragment, GSDMD-N13 translocates to the nucleus, inducing CIITA and major histocompatibility complex class ...
Liam B. Healy, Gang Du, Hao Wu
openaire   +2 more sources

mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity

Molecular Neurobiology, 2022
Developmental sevoflurane exposure leads to neuronal cell death, and subsequent learning and memory cognitive defects. The underlyi\ng mechanism remains to be elucidated. Gasdermin D (GSDMD)-mediated pyroptosis is a form of inflammatory cell death and participates in a variety of neurodegenerative diseases.
Wang, Wen-Yuan, Yi, Wan-Qing, Hu, Qi-Yun, Liu, Yu-Si, Qian, Shao-Jie, Liu, Jin-Tao, Mao, Hui, Cai, Fang, Yang, Hui-Ling   +8 more
openaire   +2 more sources

GSDMD-mediated pyroptosis in retinal vascular inflammatory diseases: a review

International Ophthalmology, 2022
Pyroptosis is a newly discovered form of programmed pro-inflammatory cell death. The main signaling pathways include the classical scorch death pathway that depends on NLRP3 inflammatory vesicles and other activation caspase-1 and the non-classical scorch death pathway that depends on caspase-4 /5/11. The substrate of all inflammatory caspases is GSDMD;
Li, Xiaodong, Xie, Xuejun
openaire   +2 more sources

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Nature, 2015
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis.
Jianjin Shi, Yue Zhao
exaly   +3 more sources

PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury

Inflammation, 2023
Cardiac insufficiency is a common complication of sepsis with high mortality. Inflammatory programmed cell death (pyroptosis) executed by NLRP3/gasdermin D (GSDMD) is intrinsically correlated with septic myocardial injury. However, it remains unclear whether PIK3CG, a classical target of septic myocardial injury, can affect pyroptosis by regulating ...
Chenxi, Lu, Jie, Liu, Germaine, Escames, Yang, Yang, Xue, Wu, Qiong, Liu, Junmin, Chen, Yanbin, Song, Zheng, Wang, Chao, Deng, Darío, Acuña-Castroviejo, Xue, Wang   +11 more
openaire   +2 more sources

SUMOylation regulates GSDMD stability and pyroptosis

International Immunopharmacology
Various post-translational modifications (PTMs), such as palmitoylation, acetylation, and ubiquitination, have been shown to regulate pyroptosis. However, the role of small ubiquitin-like modifier (SUMO) modification, known as SUMOylation, in regulating GSDMD activity and pyroptosis remains unclear.
Yuhua Shi, Xinyue Li, Weilv Xu, Yumeng Wang, Lu Dong, Danyue Li, Suhui He, Yang Yang, Nan Chen, Xinyu Fu, Fushan Shi   +10 more
openaire   +2 more sources