Results 271 to 280 of about 18,138 (288)
Some of the next articles are maybe not open access.
Targeting GSDMD JX06 inhibits PANoptosis and multiple organ injury
Biochemical PharmacologyMultiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS. Therefore,
Shiyi, Chen +7 more
openaire +2 more sources
Analyzing Caspase-8-Dependent GSDMD Cleavage in Response to Yersinia Infection
2023Caspase-8 is best known to drive an immunologically silent form of cell death known as apoptosis. However, emerging studies revealed that upon pathogen inhibition of innate immune signalling, such as during Yersinia infection in myeloid cells, caspase-8 associates with RIPK1 and FADD to trigger a proinflammatory death-inducing complex.
Felicia Hui Min, Chan, Kaiwen W, Chen
openaire +2 more sources
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Nature Cell BiologyGasdermin D (GSDMD) is the executor of pyroptosis, which is important for host defence against pathogen infection. Following activation, caspase-mediated cleavage of GSDMD releases an amino-terminal fragment (GSDMD-NT), which oligomerizes and forms pores in the plasma membrane, leading to cell death and release of proinflammatory cytokines. The spatial
Jian Zhang, , Zhongwen Chen
exaly +3 more sources
Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases
Cellular ImmunologyPyroptosis, a form of inflammatory programmed cell death, plays a pivotal role in the pathogenesis of various diseases. This process is primarily mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3).
Peipei Chen +7 more
openaire +2 more sources
Igniting hope: Harnessing NLRP3 inflammasome-GSDMD-mediated pyroptosis for cancer immunotherapy
Life SciencesIn the contemporary landscape of oncology, immunotherapy, represented by immune checkpoint blockade (ICB) therapy, stands out as a beacon of innovation in cancer treatment. Despite its promise, the therapy's progression is hindered by suboptimal clinical response rates.
Ling-Rui, Li, Lei, Chen, Zhi-Jun, Sun
openaire +2 more sources