Results 201 to 210 of about 6,248 (265)

Gasdermin-Mediated Pyroptosis in Hidradenitis Suppurativa: Molecular Insights and Therapeutic Implications. [PDF]

Biology (Basel)
Tyczyńska K, Krajewski PK, Sójka A, Nowicka-Suszko D, Bednarz-Misa I, Fleszar M, Krzystek-Korpacka M, Szepietowski JC.   +7 more
europepmc   +1 more source

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages. [PDF]

Front Immunol
Gan YQ, Cai YW, Liang XW, Wang LZ, Shi FL, Sun N, Li YP, Xu R, Hu B, Zha QB, He XH, Wong TS, Li JH, Ouyang DY.   +13 more
europepmc   +1 more source

Cracking the code of cancer immunotherapy resistance: emerging roles of pyroptosis and necroptosis. [PDF]

J Exp Clin Cancer Res
Lei K, Chen J, Deng Y, Peng Y, Zhai X, Ren X, Zhao J, Chen B, Jiang C.   +8 more
europepmc   +1 more source

Pyroptosis-immune cell cross talk in asthma: From molecular mechanisms to precision therapeutics. [PDF]

Front Immunol
Ni FX, Wang HX, Chen PS, Huang HJ, Chen HH, Huang DH, Jiang ZB.   +6 more
europepmc   +1 more source

APAF1 Silencing Ameliorates Diabetic Retinopathy by Suppressing Inflammation, Oxidative Stress, and Caspase-3/GSDME-Dependent Pyroptosis

Yuanyuan Ding, Linjiang Chen, Jing Xu, Yuhan Feng, Qiong Liu   +4 more
openalex   +2 more sources

Natterin bridges IFN-φ1 and non-canonical inflammasome pathways via <i>CRFB1</i>/Gbp4 to license Caspy2-mediated antibacterial immunity. [PDF]

Front Cell Infect Microbiol
Gusso D, Pinto FJ, Andrade-Barros AI, Bernardo JTG, DeOcesano-Pereira C, Lopes-Ferreira M, Lima C.   +6 more
europepmc   +1 more source

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, 2023
Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...

exaly   +5 more sources

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Full-length GSDME mediates pyroptosis independent from cleavage

Nature Cell Biology
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates nuclear PARP1, leading to extensive formation of ...
Bo Zhou, Zhi-Hong Jiang, Meng-Ran Dai, Yuan-li Ai, Li Xiao, Chuan-Qi Zhong, Liu-zheng Wu, Qi-Tao Chen, Hang-zi Chen, Qiao Wu   +9 more
semanticscholar   +3 more sources

Streptococcus anginosus promotes gastric cancer progression via GSDME-mediated pyroptosis pathway: Molecular mechanisms of action of GSDME, cleaved caspase-3, and NLRP3 proteins.

International Journal of Biological Macromolecules
Streptococcus vasculosus is a common oral and intestinal symbiotic bacteria, but it can transform into a pathogen under certain conditions, affecting the host's immune response. Studies have shown that Streptococcus vasculosus may promote tumor growth and metastasis by activating host inflammatory responses.
Zeshen Wang, Ruishu Mou, Shiyang Jin, Qiancheng Wang, Yuming Ju, Pengcheng Sun, Rui Xie, Kuan Wang   +7 more
semanticscholar   +3 more sources

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

Cell Death and Differentiation, 2021
Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain generation determined the RTC fate response to TNFα under the condition of oxygen-glucose-serum deprivation ...
Hui Chen, Hong Chen, Hui Yao Lan
exaly   +3 more sources