Results 211 to 220 of about 6,248 (265)

CASP3-GSDME-mediated trophoblast pyroptosis contributes to systemic inflammation

bioRxiv
Abstract Early-onset preeclampsia (EOPE) is associated with excessive apoptosis and inflammation, but the mechanistic link between these processes remains enigma. Here, we report elevated circulating pro-apoptotic proteins in EOPE patients at early pregnancy, along with concurrent CASP3 activation and GSDME cleavage in a subset of EOPE ...
Baoying Huang, Shilei Bi, Weinan Deng, L. Du, Lijun Huang, Yifan Wang, Lizi Zhang, Zhoushan Feng, Tengfei Liu, Julia Kzhyshkowska, Zhaowei Tu, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +14 more
semanticscholar   +2 more sources

Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma

Cellular & Molecular Immunology
Despite the notable efficacy of anti-PD1 therapy in the management of hepatocellular carcinoma (HCC) patients, resistance in most individuals necessitates additional investigation. For this study, we collected tumor tissues from nine HCC patients receiving anti-PD1 monotherapy and conducted RNA sequencing.
Shiping Chen, Peiling Zhang, Guiqi Zhu, Biao Wang, Jialiang Cai, Lina Song, Jinglei Wan, Yi Yang, Jun-Ze Du, Yufan Cai, Jian Zhou, Jia Fan, Zhi Dai   +12 more
semanticscholar   +3 more sources

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

Biochemical and Biophysical Research Communications, 2018
Gastric cancer is a malignancy that starts from the cells in the stomach with relatively low overall survival rate. Chemotherapy following resection surgery has been recommended as a curative strategy for gastric cancer. However, the mechanism of the chemotherapy drugs on gastric cancer is not completely understood.
Xuejun Sun
exaly   +3 more sources

GSDME: A Potential Ally in Cancer Detection and Treatment

Trends in Cancer, 2021
Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be implemented in cancer diagnosis, monitoring, and therapy.
Ibrahim, Joe, De Schutter, Erik, op de Beeck, Ken   +2 more
openaire   +3 more sources

Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis

International Immunopharmacology, 2023
The inflammatory response is one of the host's mechanisms to combat pathogens. Normal and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis, the host often exhibits an excessive inflammatory response to infection, leading to tissue and organ damage.
Chaoze Jiao, Haidan Zhang, Hongyao Li, Xu Fu, Yujie Lin, Chenglong Cao, Shixian Liu, Yijing Liu, Peiwu Li   +8 more
openaire   +2 more sources

Identification of duck GSDME: Tissue distribution, proteolysis and cellular location

Cytokine, 2022
Gasdermin E (GSDME) is a member of the gasdermin family. Cleavage of mammalian GSDME by apoptotic caspases or granzyme proteases liberates the N-terminal effector domain (GSDME-N), which is capable of forming membrane pores and executing inflammation and cell death.
Yao, Cheng, Shun, Chen, Bowen, Jiang, Weiqiong, Chen, Mingshu, Wang, Renyong, Jia, Dekang, Zhu, Mafeng, Liu, Xinxin, Zhao, Qiao, Yang, Ying, Wu, Shaqiu, Zhang, Juan, Huang, Sai, Mao, Xumin, Ou, Qun, Gao, Di, Sun, Ling, Zhang, Leichang, Pan, Anchun, Cheng   +19 more
openaire   +2 more sources

Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

Life Sciences, 2020
This study was aimed to investigate the role of GSDME-mediated pyroptosis in cardiac injury induced by Doxorubicin (DOX), and to evaluate the role of BH3-only protein Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (Bnip3) in regulation of DOX-induced pyroptosis.HL-1 cardiomyocytes and C57BL/6J mice were treated by DOX to establish DOX-induced ...
Deling Yin
exaly   +4 more sources

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Cell Research, 2023
AbstractPyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexose, inhibits GSDME-mediated pyroptosis by activating AMP-activated protein kinase (AMPK).
Hang-Zi Chen, Wen-Bin Hong, Qiao Wu
exaly   +3 more sources

Gsdme Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils

Blood, 2023
Introduction Neutrophil extracellular traps (NETs) neutralize bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4), is synonymous with NETosis and is considered independent of ...
Yanfang Peipei Zhu, Mary Helen Speir, ZheHao G Tan, Harold M Hoffman, Lai Ping Wong, Ruslan Sadreyev, Kate L Jeffrey, Ben A Croker   +7 more
openaire   +1 more source

Honokiol‐Magnolol‐Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti‐PD‐1 Immunotherapy in Colorectal Cancer by Triggering GSDME‐Dependent Pyroptosis

Advancement of science
Significant progress is made in the treatment of metastatic colorectal cancer (mCRC) patients, however, therapeutic options remain limited for patients with mCRC. In recent years, traditional Chinese medicine (TCM) has gained significant attention. Among
Quan Gao, Qinsong Sheng, Zijing Yang, Zhiyu Zhu, Lin Li, Lihui Xu, Jing Xia, Yunhao Qiao, Jie Gu, Xiaolong Zhu, Tian Xie, Xinbing Sui   +11 more
semanticscholar   +1 more source