Results 231 to 240 of about 6,248 (265)

GSDME-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation.

British Journal of Dermatology
OBJECTIVE Psoriasis is a common, chronic inflammatory disease with unclear etiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death.
Yingfei Li, Yi He, Fangyuan Yang, Rongmei Liang, Wenchao Xu, Yehao Li, Jingbo Cheng, Baozhu Liang, Ming Tang, Xingliang Shi, Zhuang Jian, Minshuang Luo, Liuying Li, Ruilin Zhang, Huijuan Liu, H. Jie, Xing Li, Xinai Han, Erwei Sun, Z. Zhai   +19 more
semanticscholar   +1 more source

[Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor ...
Liting, Peng, Xi, Wang, Weiqian, Wang, Jincao, Xu, Xue, Gao   +4 more
openaire   +1 more source

Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis

Cell Death and Disease
Immune checkpoint inhibitors (ICIs) have significant therapeutic effects but can also cause fatal lung injury. However, the lack of mouse animal models of ICI-related lung injury (ICI-LI) has limited the in-depth exploration of its pathogenesis.
Fei Wang, H. Deng, Maolin Zhou, Yilin Yang, Jiankui Zhou, Yansheng Wang, Xiaohong Xie, Xinqing Lin, Ming Liu, Gengyun Sun, Chengzhi Zhou   +10 more
semanticscholar   +1 more source

Exosomal ALKBH5 Alleviates Vascular Calcification by Suppressing Cell Apoptosis via m6A‐Modified GSDME

Drug development research (Print)
This study aimed to explore the function and regulatory mechanism of ALKBH5 in the progression of coronary artery calcification. Human aortic vascular smooth muscle cells (HA‐VSMCs) were treated with inorganic phosphate (Pi) and exosomes derived from ...
Guian Xu, Qingman Li, Lijie Zhu, Tingjie Yang, Yapan Yang, Honghui Yang   +5 more
semanticscholar   +1 more source

GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Blood
Abstract Thrombotic complications due to platelet hyperreactivity are a major cause of death in patients undergoing chemotherapy. However, the underlying mechanisms are not fully understood. Herein, using human platelets and platelets from mice lacking gasdermin E (GSDME), we show that GSDME is functionally ...
Ruyi Xue, Min Li, Ge Zhang, Wei Zhang, Liping Han, Tao Bo, Haoxuan Zhong, Dingjin Yao, Yiran Deng, She Chen, Si Zhang   +10 more
openaire   +2 more sources

GSDMD and GSDME synergy in the transition of acute kidney injury to chronic kidney disease.

Nephrology, Dialysis and Transplantation
BACKGROUND AND HYPOTHESIS Acute kidney injury (AKI) could progress to chronic kidney disease (CKD) and the AKI-CKD transition has major clinical significance. A growing body of evidence has unveiled the role of pyroptosis in kidney injury.
Zhengyue Chen, Caiming Chen, Kunmei Lai, Chengkun Wu, Fan Wu, Zhimin Chen, K. Ye, Jingzhi Xie, Huabin Ma, Hong Chen, Yujia Wang, Yanfang Xu   +11 more
semanticscholar   +1 more source

Alpinumisoflavone triggers GSDME-dependent pyroptosis in esophageal squamous cell carcinomas.

Anatomical record (Hoboken, N.J. : 2007), 2021
Esophageal squamous cell carcinoma (ESCC) presents a common human malignancy in the digestive system. We aimed to explore the critical effects of alpinumisoflavone (AIF) on ESCC in vitro and in vivo. The cell counting kit-8 assay was used to determine cell viability.
Bin, Zhang, Wen-Yong, Zhu, Hui, Tian, Huan-Rong, Zhang   +3 more
openaire   +1 more source

Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction

BMC Pharmacology and Toxicology
Acute myocardial infarction (AMI) is a leading fatal cardiovascular disease and poses a major threat to human health. Pyroptosis, an inflammation-related programmed cell death, plays a critical role in the progression of AMI.
Jie Zhou, Huifei Zhou, Jianfeng Zhu, Shunjin Fang   +3 more
semanticscholar   +1 more source

Euphohelioscopin A enhances NK cell antitumor immunity through GSDME-triggered pyroptosis

Journal of Leukocyte Biology
Abstract Immune evasion by cancer cells poses a significant challenge for natural killer cell–based immunotherapy. Pyroptosis, a newly discovered form of programmed cell death, has shown great potential for enhancing the antitumor immunity of natural killer cells.
Chenyuan Gong, Hongyan Mu, Jiaojiao Luo, Rujun Zhang, Dan Hu, Zhenhua Chen, Cheng Fang, Zhongxian Chen, Xinxue Zhu, Chao Yao, Lixin Wang, Yufu Zhou, Weimin Zhao, Shiguo Zhu   +13 more
openaire   +2 more sources

Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Objective Investigating the effects and mechanisms of dapagliflozin on pyroptosis of renal tubular epithelial cells under high-glucose conditions through the regulation of the Caspase-3/GSDME signaling pathway, providing experimental evidence for the ...
Hong Jiang, Mengya Gao, Jiaqi Liu, Lijuan Yang, Lei Liu   +4 more
semanticscholar   +1 more source