Results 241 to 250 of about 6,248 (265)

High glucose promotes lipopolysaccharide‐induced macrophage pyroptosis through GSDME O‐GlcNAcylation

Journal of Periodontal Research
AbstractAimThe high glucose (HG) environment in diabetic periodontitis aggravates the damage of periodontal tissue. Pyroptosis has been shown to be positively correlated with the severity of periodontitis, including macrophage pyroptosis. O‐GlcNAcylation is a posttranslational modification that is involved in the pathogenesis of periodontitis. However,
openaire   +2 more sources

Inhibiting apoptosis and GSDME-mediated pyroptosis attenuates hepatic injury in septic mice

Archives of Biochemistry and Biophysics
Sepsis is characterized by severe inflammation and organ dysfunction resulting from a dysregulated organismal response to infection. Although pyroptosis has been presumably shown to be a major cause of multiple organ failure and septic death, whether gasdermin E (GSDME)-mediated pyroptosis occurs in septic liver injury and whether inhibiting apoptosis ...
Na Lu, Hongqian Qin, Zhaofei Meng, Ying Yu, Qin Gao, Zhipeng Cheng, Chuanmiao Liu, Junfeng Hu   +7 more
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LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression

Cancer Cell International
Platinum-based chemotherapy is the standard first-line cancer treatment. However, patients experience relapses due to chemoresistance. We found that long non-coding RNA 16 (lncRNA16) promotes platinum resistance and inhibits cell death in non-small cell ...
Yanfang Liu, Yuanjun Zeng, Sikai Wang, Jiangyan Chen, Zhouqi Wang, Yang Zhao, Kuiyu Gong, Guihua Wang   +7 more
semanticscholar   +1 more source

GSDME as an executioner of chemotherapy-induced cell death

Science China Life Sciences, 2017
Xiaoliang, Yu, Sudan, He
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Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

Cell Death and Disease, 2021
Jinah Park, Kyoungwha Pang, Yuna Park
exaly  

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Cell Death Discovery, 2020
Yanjing Li
exaly  

Photodynamic therapy induces human esophageal carcinoma cell pyroptosis by targeting the PKM2/caspase-8/caspase-3/GSDME axis

Cancer Letters, 2021
, Yuxian Bai
exaly  

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Cell Death Discovery, 2022
Weirong Wang, Jianli Gu, Rong Lin
exaly  

GSDME-mediated pyroptosis in microglia exacerbates demyelination and neuroinflammation in multiple sclerosis: insights from humans and cuprizone-induced demyelination model mice

Cell Death and Differentiation
Danjie Wang, Tongtong Zhang, Qi Shao, Xinyi Wu, Xiaoqiang Zhao, Hongyu Zhang, Yu-meng Wang, Jing-xian Sun, Xuechun Chang, Keying Zhu, Shuai Wu, Li Cao, Wankun Chen, Jun Wang   +13 more
semanticscholar   +1 more source

Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME

Science China Life Sciences, 2018
Xixi, Zhang, Haibing, Zhang
openaire   +2 more sources