Results 291 to 300 of about 360,657 (334)

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy.

Angewandte Chemie, 2019
The generation of singlet oxygen (1 O2 ) during photodynamic therapy is limited by the precise cooperation of light, photosensitizer, and oxygen, and the therapeutic efficiency is restricted by the elevated glutathione (GSH) levels in cancer cells ...
Chao Wang, Fengjuan Cao, Yudi Ruan, Xiaodan Jia, Wenyao Zhen, Xiue Jiang   +5 more
semanticscholar   +1 more source

Fluorometric estimation of GSH-OPT

Analytical Biochemistry, 1968
Abstract Cohn and Lyle (1) have reported that under certain conditions reduced glutathione (GSH) and o-phthalaldehyde (OPT) react to produce a highly fluorescent compound, and that no other compound tested, including GSSG and 16 other sulfhydryl, disulfide, or thioether compounds, yields fluorescence with OPT under those conditions.
T L, McNeil, L V, Beck
openaire   +2 more sources

Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1992
There is a growing interest in the therapeutic use of sulfhydryls. To assess the effect of glutathione (GSH) and cysteine on the cellular thiol status, thiols were administered intravenously to rats in doses ranging from 1.67 to 8.35 mmol/kg with and without pretreatment with 4 mmol/kg buthionine-[S,R]-sulfoximine (BSO), an inhibitor of GSH synthesis.
S, Aebi, B H, Lauterburg
openaire   +2 more sources

Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms.

DNA and Cell Biology, 2020
Epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) is thought to be involved in the pathogenesis of pulmonary fibrosis. Emerging evidence suggested that there are some common causes between ferroptosis and pulmonary
Lulu Sun, Hongliang Dong, Weiqun Zhang, Nan Wang, Na Ni, Xuelian Bai, Naiguo Liu   +6 more
semanticscholar   +1 more source

The relationship between GSH, GSSG and non-GSH thiol in GSH-deficienct erythrocytes from finnish landrage and tasmanian merino sheep

Biochimica et Biophysica Acta (BBA) - General Subjects, 1975
1. Two automated colorimetric methods have been developed for assaying the GSH and total thiol in protein-free extracts of erythrocytes. They employ as chromogens 5,5'-dithiobis-(2-nitrobenzoate) (DTNB) and alloxan. 2. The concentrations of GSH, GSSG and total non-protein thiol have been estimated in high and low GSH erythrocytes from Finnish Landrace ...
J D, Young, I A, Nimmo, J G, Hall
openaire   +2 more sources

GSH and analogs in antiviral therapy

Molecular Aspects of Medicine, 2009
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de novo and salvage synthesis serves to maintain a reduced cellular environment. GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S ...
Alessandra Fraternale, Maria Filomena Paoletti, Anna Casabianca, NENCIONI, Lucia, Enrico Garaci, PALAMARA, ANNA TERESA, Mauro Magnani   +6 more
openaire   +4 more sources

Targeted GSH-exhausting and hydroxyl radical self-producing manganese-silica nanomissiles for MRI guided ferroptotic cancer therapy.

Nanoscale, 2020
Ferroptosis, a cell death path induced by the generation of reactive oxygen species (ROS), will cause the accumulation of lipid peroxides (PL-PUFA-OOH) and achieve potent tumor-regression.
Weidong Fei, Danfei Chen, Hongxia Tang, Chaoqun Li, Weizeng Zheng, Fengying Chen, Qianqian Song, Yunchun Zhao, Y. Zou, Caihong Zheng   +9 more
semanticscholar   +1 more source

AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy.

Chemical Communications, 2020
A novel ferrocene decorated vinyl pyridinium-substituted tetraphenylethylene (TPEPY-S-Fc) linked by a disulfide bond was designed as a GSH activatable photosensitizer by aggregation-induced emission for imaging-guided photodynamic therapy of cancer cells.
Youhui Zhang, X. Li, Li Huang, Hyeong Seok Kim, J. An, Minhuan Lan, Qian‐Yong Cao, Jong Seung Kim   +7 more
semanticscholar   +1 more source

GSH CONJUGATING ENZYME

Archives of Pediatrics & Adolescent Medicine, 1968
To the Editor .—Recently Krasner and Yaffe 1 reported observations on the development of GSH aryl-transferase activity in mouse liver during the neonatal period. They also tried to enhance such enzymatic activity in the newborn mouse by injecting phenobarbital and substrate (sulfobromophthalein [BSP]) into the mother at the end of the pregnancy ...
openaire   +1 more source

Xenobiotic Detoxification by GSH-Loaded Erythrocytes

1992
It is well known that the cells of higher organisms are able to excrete unwanted foreign chemicals (pesticides, herbicides, aromatic amines used in the dye industries, etc.) after metabolic conversion. An important role in this process is performed by reduced glutathione (GSH) which is present at high concentrations (2mM) in all living cells.
A. FAZI, U. MANCINI, E. PIATTI, A. ACCORSI, MAGNANI, MAURO   +4 more
openaire   +4 more sources