Results 61 to 70 of about 153,861 (265)

Similarities between GSH, hypoplasticity and KCR [PDF]

Acta Geotechnica, 2016
Accounting for elasto-plastic motion in granular media, hypoplasticity is a state-of-the-art constitutive model derived from data accumulated over many decades. In contrast, GSH, a hydrodynamic theory, is derived from general principles of physics, with comparatively few inputs from experiments, yet sporting an applicability ranging from static stress ...
Jiang, Yimin, Liu, Mario
openaire   +2 more sources

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

A IMPLANTAÇÃO DA TROCA AUTOMATIZADA DE GLÓBULOS VERMELHOS (ERITROCITAFÉRESE) COMO MODALIDADE DE TRATAMENTO EM PACIENTES COM DOENÇA FALCIFORME: EXPERIÊNCIA DO AMBULATÓRIO TRANSFUSIONAL SERUM CENTRO – RJ

Hematology, Transfusion and Cell Therapy
Introdução: A Doença Falciforme (DF) é uma doença genética e hereditária caracterizada por uma mutação no gene que produz a hemoglobina (HbA), fazendo surgir uma hemoglobina mutante denominada S (HbS).
PG Moura, MS Simão, LA Nunes, RL Lima, L Avelar, FN Lima, PCP Grossi, IG Claudio, F Akil   +8 more
doaj   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

IMPACTO DA TRANSFUSÃO DE TROCA AUTOMATIZADA EM PACIENTE COM DOENÇA FALCIFORME DE EVOLUÇÃO GRAVE CURSANDO COM HEMATOPOIESE EXTRAMEDULAR– RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Resumo: Relato de caso de paciente de 15 anos com Doença Falciforme (DF)de evolução grave, com surgimento de lesão paravertebral evidenciada em exame de ressonância nuclear magnética (RNM), sugerindo hematopoiese extramedular (HEM) e que obteve resolução
PG Moura, VLR Pessoa, BL Raposo, MS Simão, LA Nunes, C Rebello, IG Claudio, RL Lima, L Avelar, F Akil   +9 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

REAÇÃO HEMOLÍTICA AGUDA APÓS TRANSFUSÃO DE PLAQUETAS ABO INCOMPATÍVEL: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: A transfusão de concentrado de plaquetas (CP) deve idealmente ser ABO-isogrupo, entretanto o uso de CP não idênticas não são incomuns devido baixa disponibilidade de todos os tipos sanguíneos e a vida-média curta de 5 dias destes ...
SMC Lira, IGP Silva, JPL Amorim, EC Ferreira, PDS Teixeira, WWV Sampaio, M Valvasori, LFF Dalmazzo   +7 more
doaj   +1 more source