GSK-3 and Tau: A Key Duet in Alzheimer’s Disease [PDF]
Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a central position in cell metabolism and signaling, with important roles both ...
Carmen Laura Sayas, Jesús Ávila
exaly +4 more sources
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention [PDF]
Leukemia, 2013 Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated and inactivated glycogen synthase.
Giuseppe Montalto +2 more
exaly +4 more sources
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment [PDF]
Cells, 2020 The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes,
Giuseppa Augello +6 more
doaj +7 more sources
Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies [PDF]
Cells, 2022 Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously expressed, multifunctional serine/threonine protein kinase involved in the regulation of a variety of physiological processes.
Alberto M. Martelli +4 more
doaj +2 more sources
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase [PDF]
Frontiers in Molecular Neuroscience, 2012 Glycogen synthase kinase 3 (GSK-3) is an evolutionarily conserved multifaceted ubiquitous enzyme. In the central nervous system (CNS), GSK-3 acts through an intricate network of intracellular signaling pathways culminating in a highly divergent cascade ...
Norelle Christine Wildburger +5 more
doaj +2 more sources
GSK-3 mouse models to study neuronal apoptosis [PDF]
Frontiers in Molecular Neuroscience, 2011 Increased GSK-3 activity is believed to contribute to the etiology of chronic disorders like Alzheimer’s disease, schizophrenia, diabetes and some types of cancer, thus supporting therapeutic potential of GSK-3 inhibitors.
Raquel eGomez-Sintes +7 more
doaj +2 more sources
Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance [PDF]
Cells, 2022 Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases.
Manisha Gupte +5 more
doaj +2 more sources
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house ...
Paula Martínez de Iturrate +9 more
doaj +2 more sources
GSK-3: Functional Insights from Cell Biology and Animal Models
Frontiers in Molecular Neuroscience, 2011 Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related proteins: GSK-3α and GSK-3β.
Oksana Kaidanovich-Beilin
exaly +3 more sources
GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis. [PDF]
Front Mol Biosci, 2021 Cinetto F +14 more
europepmc +2 more sources