Results 1 to 10 of about 106,875 (237)
The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment [PDF]
Cells, 2020 The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes,
Giuseppa Augello +6 more
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Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies [PDF]
Cells, 2022 Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously expressed, multifunctional serine/threonine protein kinase involved in the regulation of a variety of physiological processes.
Alberto M. Martelli +4 more
doaj +2 more sources
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease [PDF]
Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a central position in cell metabolism and signaling, with important roles both ...
Carmen Laura Sayas, Jesús Ávila
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Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance [PDF]
Cells, 2022 Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases.
Manisha Gupte +5 more
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Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house ...
Paula Martínez de Iturrate +9 more
doaj +2 more sources
GSK-3 inhibitors: preclinical and clinical focus on CNS [PDF]
Frontiers in Molecular Neuroscience, 2011 Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has become an important target for treating neurodegenerative and psychiatric disorders.
Hagit eEldar-Finkelman, Ana eMartinez
doaj +4 more sources
GSK-3 inhibitors induce chromosome instability [PDF]
BMC Cell Biology, 2007 Background Several mechanisms operate during mitosis to ensure accurate chromosome segregation. However, during tumour evolution these mechanisms go awry resulting in chromosome instability.
Staples Oliver D +3 more
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Lithium and Therapeutic Targeting of GSK-3. [PDF]
Cells, 2021 Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders. However, the remarkable effects of lithium reported by John Cade and subsequently by Mogens Schou revolutionized the treatment of bipolar ...
Snitow ME, Bhansali RS, Klein PS.
europepmc +5 more sources
GSK‐3 in Neurodegenerative Diseases [PDF]
International Journal of Alzheimer’s Disease, 2011 Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis of diverse diseases. In this paper we will focus on the dysfunction of GSK‐3 in Alzheimer’s disease and Parkinson’s disease. Specifically, GSK‐3 is known to interact with tau, β‐amyloid (Aβ), and α‐synuclein, and as such may
Lei, P, Ayton, S, Bush, AI, Adlard, PA
openaire +4 more sources
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. [PDF]
Proc Natl Acad Sci U S A, 2021 AbstractThe coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome (MERS-CoV), and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral replication, transcription, and virion assembly.
Liu X +18 more
europepmc +7 more sources