GSK-3 and Tau: A Key Duet in Alzheimer’s Disease [PDF]
Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a central position in cell metabolism and signaling, with important roles both ...
Carmen Laura Sayas, Jesús Ávila
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The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment [PDF]
Cells, 2020 The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes,
Giuseppa Augello +6 more
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Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. [PDF]
Proc Natl Acad Sci U S A, 2021 The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome (MERS-CoV), and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral ...
Liu X +18 more
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Lithium and Therapeutic Targeting of GSK-3. [PDF]
Cells, 2021 Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders.
Snitow ME, Bhansali RS, Klein PS.
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Regulation of Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway. [PDF]
Int J Mol Sci, 2022 Autophagy is a vital cellular mechanism that benefits cellular maintenance and survival during cell stress. It can eliminate damaged or long-lived organelles and improperly folded proteins to maintain cellular homeostasis, development, and ...
Pan HY, Valapala M.
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Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies [PDF]
Cells, 2022 Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously expressed, multifunctional serine/threonine protein kinase involved in the regulation of a variety of physiological processes.
Alberto M. Martelli +4 more
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Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration. [PDF]
Cells, 2021 Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to public health. There is currently no adequate therapy for these disorders, and therefore there is an urgent need to accelerate the discovery and development of ...
Rippin I, Eldar-Finkelman H.
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Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro
BMC Cancer, 2018 Background Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal.
Selvi Kunnimalaiyaan +4 more
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Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance [PDF]
Cells, 2022 Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases.
Manisha Gupte +5 more
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Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house ...
Paula Martínez de Iturrate +9 more
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