Results 101 to 110 of about 16,343,665 (315)
Cystatin C as Biomarker for the Evaluation of Renal Outcome in AL Amyloidosis
American Journal of Hematology, EarlyView.ABSTRACT Cystatin C (CysC) has emerged as a novel and potentially more reliable biomarker for the estimation of glomerular filtration in the general population in patients with various conditions. In AL amyloidosis, the current renal staging system and renal response criteria are based on proteinuria and creatinine‐based eGFR.
Foteini Theodorakakou +18 more
wiley +1 more source
Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2 + 2]‐Cycloadditions
Angewandte Chemie, EarlyView.In this study, we capitalize on the versatility offered by genetic code expansion to develop a proficient photoenzyme for [2 + 2]‐cycloadditions that is enantiocomplementary to our recently developed photoenzyme EnT1.3. By repositioning the genetically programmed benzophenone photosensitizer and subsequent directed evolution, we have developed an ...
Chuanjie Sun +9 more
wiley +2 more sources
Neoplasia: An International Journal for Oncology Research, 2008 The glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in mammalian tissues. Ini-tially identified by its ability to modulate glycogen synthesis, GSK-3 turned out to be a multifunctional enzyme, able to phosphorylate many ...
Ludwig Rinnab +7 more
doaj +1 more source
GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells.
Oncology Report, 2016 Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that functions in numerous signaling pathways initiated by diverse stimuli. The functions of GSK-3 in cancer differ depending on cell type. In the present study, we examined the effects of a
Hideki Nishimura +6 more
semanticscholar +1 more source
Asian Journal of Organic Chemistry, EarlyView.A new protocol to prepare 2‐aryl‐3‐(arylselanyl)imidazo[1,2‐a]pyridines under blue light irradiation, using benzeneseleninic acid derivatives as selenium source, is described. The experimental design approach (DoE) was used to establish the best reaction conditions, which delivered fourteen derivatives in moderate to good yields (23%–75%) using water ...
Caroline S. Gomes +6 more
wiley +1 more source
GSK-3 protein and the heart: friend or foe?
SA Heart, 2017 Metabolic syndrome manifesting as obesity, insulin resistance and type 2 diabetes mellitus is currently pandemic. Each of these, in its own right, is strongly related to the development of cardiovascular disease. The cardiomyopathy associated with these disorders is characterised by curtailed glucose uptake and utilisation, elevated risk of damage ...
Amanda Lochner, Barbara Huisamen
openaire +4 more sources
ACS Medicinal Chemistry Letters, 2015 Quantifying glycogen synthase kinase-3 (GSK-3) activity in vivo using positron emission tomography (PET) imaging is of interest because dysregulation of GSK-3 is implicated in numerous diseases and neurological disorders for which GSK-3 inhibitors are ...
Lei Li +12 more
semanticscholar +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Temperature‐controlled radiofrequency (TCRF) ablation of the posterior nasal nerve has been shown to improve chronic rhinitis (CR) symptoms and quality of life (QoL). This study assesses the durability of TCRF's effectiveness and safety 3 years post‐procedure in patients with perennial allergic CR and nonallergic CR.
J. Pablo Stolovitzky +8 more
wiley +1 more source
CDK versus GSK-3 Inhibition [PDF]
Chemistry & Biology, 2003 The ubiquitous ATP binding site offers a global target for protein kinase inhibitors. The corollary is that molecular selectivity with such agents may be difficult to achieve and ascertain. A relevant example is discussed in terms of design and biomedical rationale.
openaire +3 more sources