Results 111 to 120 of about 16,343,665 (315)
HPB, 2015 BACKGROUND Glycogen synthase kinase-3 (GSK-3) can act as either a tumour promoter or suppressor by its inactivation depending on the cell type. There are conflicting reports on the roles of GSK-3 isoforms and their interaction with Notch1 in pancreatic ...
S. Kunnimalaiyaan +2 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source
Heterocyclic GSK-3 allosteric modulators
, 2011 Consejo Superior de Investigaciones Científicas (España)
Martínez Gil, Ana +5 more
openaire +11 more sources
The effects of clozapine on the GSK‐3‐mediated signaling pathway
FEBS Letters, 2004 We investigated the effect of 10 μM clozapine on the activity of glycogen synthase kinase‐3β (GSK‐3β) and its upstream and downstream molecules in SH‐SY5Y human neuroblastoma cells. Clozapine activates both Akt‐ and Dvl‐mediated phosphorylation of GSK‐3β through phosphorylation at Ser9, and increased total cellular and intranuclear levels of β‐catenin.
Yong Sik Kim +5 more
openaire +3 more sources
Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3 [PDF]
, 2000 Toshiaki Ohteki +6 more
openalex +1 more source
Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges
Animal Models and Experimental Medicine, EarlyView.Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley +1 more source
Marine Drugs, 2016 The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling pathways of type 2 diabetes, neurological disorders, cancer, and other diseases.
Jutta Wiese +4 more
doaj +1 more source
Function of GSK‑3 signaling in spinal cord injury (Review). [PDF]
Exp Ther Med, 2023 Dong X, Hong H, Cui Z.
europepmc +1 more source
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification [PDF]
, 2000 Gist H. Farr +5 more
openalex +1 more source
Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation
Advanced NanoBiomed Research, EarlyView.Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos +2 more
wiley +1 more source