Results 251 to 260 of about 16,343,665 (315)

Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3β/Snail signaling in renal cell carcinoma [PDF]

, 2013
Yu Zhu, Le Xu, Jianping Zhang, Wenping Xu, Yujun Liu, Hankun Yin, Tao Lv, Huimin An, Li Liu, Hongyong He, Heng Zhang, Jing Liu, Jiejie Xu, Zongming Lin   +13 more
openalex   +1 more source

Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice

Molecular Neurobiology, 2016
E. Jung, Minhan Ka, Woo-Yang Kim
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Phosphoinositide 3-Kinase γ Inhibits Cardiac GSK-3 Independently of Akt [PDF]

, 2013
Maradumane L. Mohan, Babal K. Jha, Manveen K. Gupta, Neelakantan T. Vasudevan, Elizabeth E Martelli, J. David Mosinski, Sathyamangla V. Naga Prasad   +6 more
openalex   +1 more source

Inequalities in access to industry‐funded interventional phase I–IV drug trials in epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Clinical trials on drug safety and efficacy are understood to be valid for all humans, but are not equally distributed worldwide. We aimed to analyze the global distribution of clinical drug trials (phase I–IV) in epilepsy and its correlation with key demographical and epidemiological factors.
Robert Hoepner, Alejandro Xavier León Betancourt, Stefanie Marti, Andrea Seiler   +3 more
wiley   +1 more source

Glycogen synthase kinase‐3 (GSK‐3) regulatesTGF‐β₁‐induced differentiation of pulmonary fibroblasts [PDF]

, 2013
Hoeke A. Baarsma, Lilian H.J.M. Engelbertink, Lonneke J. van Hees, Mark H. Menzen, Herman Meurs, Wim Timens, Dirkje S. Postma, Huib A.M. Kerstjens, Reinoud Gosens   +8 more
openalex   +1 more source

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

, 2011
Heather K. Bone, Adam Nelson, Christopher E. Goldring, David Tosh, Melanie J. Welham   +4 more
openalex   +1 more source

Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3β/caveolin signalling in H9c2 rat cardiomyoblasts [PDF]

, 2013
Shih‐Ron Hsieh, Chen‐Sen Hsu, Chen-Hua Lu, Wei‐Cheng Chen, Chun-Hwei Chiu, Ying‐Ming Liou   +5 more
openalex   +1 more source