Results 291 to 300 of about 16,343,665 (315)
Are Boot Camps an Effective Teaching Modality for Junior Otolaryngology Residents?
The Laryngoscope, EarlyView.
Christopher J. Chin+4 more
wiley +1 more source
GSK-3: a multifaceted player in acute leukemias
Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to glucose metabolism regulation. However, GSK-3 is also involved in several signaling pathways controlling many different key functions in healthy cells.
A. Martelli+4 more
semanticscholar +7 more sources
Cdc42 & GSK-3: signals at the crossroads [PDF]
Cell polarity is regulated by independent pathways that are controlled by Wnt- or Cdc42-mediated signalling. Now, glycogen synthase kinase 3 (GSK-3), an established component of the Wnt pathway, is shown to interact with Par6–protein kinase C ζ (PKCζ), a complex that transduces Cdc42 signals.
Adrian J. Harwood, Vania M.M. Braga
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Schizophrenia as a GSK-3 dysregulation disorder
Trends in Neurosciences, 2007Converging evidence suggests that the regulation of glycogen synthase kinase 3 (GSK-3) might be important in schizophrenia. Atypical and typical antipsychotic drugs alter GSK-3 activity, as do drugs that induce psychosis. GSK-3 regulatory pathways are altered in schizophrenia, and many of the genes associated with schizophrenia directly or indirectly ...
Lovestone, S+3 more
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GSK-3 Inhibitors: Discoveries and Developments
Current Medicinal Chemistry, 2004Glycogen synthase kinase 3 (GSK-3) in the 21(st) century emerged as one of the most attractive therapeutic target for the development of selective inhibitors as new promising drugs for unmet pathologies including Alzheimer's disease, stroke, bipolar disorders, chronic inflammatory processes, cancer and diabetes type II.
Ana Martínez, Mercedes Alonso
openaire +3 more sources
GSK-3 and the neurodevelopmental hypothesis of schizophrenia
European Neuropsychopharmacology, 2002The Neurodevelopmental Hypothesis of schizophrenia suggests that interaction between genetic and environmental events occurring during critical early periods in neuronal growth may negatively influence the way by which nerve cells are laid down, differentiated and selectively culled by apoptosis.
Robert H. Belmaker+3 more
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Anti-inflammatory Potential of GSK-3 Inhibitors
Current Drug Targets, 2021Glycogen synthase kinase-3 (GSK-3) is a protein kinase containing threonine or serine amino acid residues. GSK-3 was first discovered in 1980 as a regulatory protein kinase, Glycogen synthase (GS) enzyme, which is responsible for the conversion of glycogen from glucose with the help of uridine diphosphate glucose (UDP-Glu) residue.
Chandi C. Kandar+2 more
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NeuroReport, 2019
The aim of this study is to investigate the protective effect of epigallocatechin-3-gallate (EGCG) on apoptosis and mTOR/AKT/GSK-3&bgr; pathway in substantia nigra neurons in 6-dopamine-induced Parkinson rats.
W. Zhou+4 more
semanticscholar +1 more source
The aim of this study is to investigate the protective effect of epigallocatechin-3-gallate (EGCG) on apoptosis and mTOR/AKT/GSK-3&bgr; pathway in substantia nigra neurons in 6-dopamine-induced Parkinson rats.
W. Zhou+4 more
semanticscholar +1 more source
Effect of GSK-3 overactivation on neurofilament phosphorylation
Journal of Huazhong University of Science and Technology [Medical Sciences], 2005In this study, we studied the effect of glycogen synthase kinase-3 (GSK-3) overactivation on neurofilament phosphorylation in cultured cells. After N2a cells were treated with the specific inhibitor (wortmannin) of phosphoinositol-3 kinase (PI-3K) or treated with wortmannin and the specific inhibitor (LiCl) of glycogen synthase kinase-3 (GSK-3), GSK-3 ...
Youmei Feng+3 more
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Biochemical Society Transactions, 2015
UNLABELLED Nuclear factor-erythroid 2 p45 (NF-E2 p45)-related factor 2 (Nrf2) is a master regulator of redox homoeostasis that allows cells to adapt to oxidative stress and also promotes cell proliferation.
J. Hayes+3 more
semanticscholar +1 more source
UNLABELLED Nuclear factor-erythroid 2 p45 (NF-E2 p45)-related factor 2 (Nrf2) is a master regulator of redox homoeostasis that allows cells to adapt to oxidative stress and also promotes cell proliferation.
J. Hayes+3 more
semanticscholar +1 more source