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GSK-3: An “Ace” Among Kinases

Cancer Biotherapy and Radiopharmaceuticals
Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase known to participate in the regulation of β-catenin signaling (Wnt signaling). This aids in the establishment of a multicomponent destruction complex that stimulates phosphorylation, leading to the destruction of β-catenin.
openaire   +2 more sources

GSK-3, Jack of All Trades

Science Signaling, 2008
Cross-talk between signaling pathways alters transcriptional regulatory activity of the glucocorticoid nuclear receptor.
openaire   +1 more source

The Saccharomyces cerevisiae GSK-3 beta homologs.

Current drug targets, 2007
Yeast cells carry four homologs of GSK-3beta, RIM11, MCK1, MRK1 and YGK3. The significant homologs are RIM11 and MCK1 that presumably arose from a recent genome duplication followed by a rapid divergence. Accordingly, these homologs phosphorylate specific substrates.
Yona, Kassir   +2 more
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GSK-3 signaling in health

Advances in Biological Regulation, 2017
James A, McCubrey, Lucio, Cocco
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GSK-3

2012
openaire   +1 more source

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

Nature, 2003
Christopher J Phiel, Peter S Klein
exaly  

GSK-3

2018
openaire   +1 more source

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