A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer [PDF]
, 2016 This is an open-access article distributed under the terms of the Creative Commons Attribution License.Expression of Glycogen Synthase Kinase-3 (GSK-3) is elevated in prostate cancer and its inhibition reduces prostate cancer cell proliferation, in part ...
Baltziskueta, Eder +6 more
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GSK-3 and mitochondria in cancer cells [PDF]
Frontiers in Oncology, 2013 GSK-3 is a multifunctional kinase that is located in the cytosol, nucleus, and mitochondria of all cell types, and it is involved in the pathogenesis of a variety of diseases. In cancer, GSK-3 modulates the response of the cell death machinery to stress stimuli, including chemotherapeutics.
CHIARA, FEDERICA, RASOLA, ANDREA
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Frontiers in Endocrinology, 2014 Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular ...
Colleen M Bartman +6 more
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Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease [PDF]
, 2015 © The Author 2015. Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by brain atrophy particularly in striatum leading to personality changes, chorea and dementia.
Alberch, Jordi +6 more
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Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity [PDF]
The International Journal of Neuropsychopharmacology, 2003 Glycogen synthase kinase (GSK)-3 protein levels and GSK-3 activity were previously found to be over 40% reduced in the post-mortem prefrontal cortex of schizophrenic patients. Lithium and valproate have been reported to selectively inhibit GSK-3. We hypothesized that in-vivo administration of lithium and valproate would result in up-regulation of GSK-3
Nitsan, Kozlovsky +3 more
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GSK-3: a multifaceted player in acute leukemias
Leukemia, 2021 Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to glucose metabolism regulation. However, GSK-3 is also involved in several signaling pathways controlling many different key functions in healthy cells.
A. M. Martelli +4 more
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Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death
BMC Cancer, 2010 Background Glycogen Synthase Kinase-3 (GSK-3) α and β are two serine-threonine kinases controlling insulin, Wnt/β-catenin, NF-κB signaling and other cancer-associated transduction pathways.
Colpo Anna +12 more
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Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation [PDF]
, 2015 Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer's Disease (AD) but the underlying mechanisms have not been fully elucidated yet.
De Chiara, Giovanna +7 more
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N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.
The Journal of biological chemistry, 2007 Peer ...
Goñi-Oliver, Paloma +3 more
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Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent. [PDF]
PLoS ONE, 2013 Glycogen synthase kinase-3 (GSK-3) inhibitors have been postulated as useful therapeutic tools for the treatment of chronic neurodegenerative and neuropsychiatric diseases.
Raquel Gómez-Sintes, José J Lucas
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