Results 31 to 40 of about 106,875 (237)

Expanding Mouse Ventricular Cardiomyocytes Through GSK‐3 Inhibition [PDF]

Current Protocols in Cell Biology, 2013
AbstractControlled proliferation of cardiomyocytes remains a major limitation in cell biology and one of the main underlying hurdles for true modern regenerative medicine. Here, a technique is described for robust expansion of early fetal‐derived mouse ventricular cardiomyocytes on a platform usable for high‐throughput molecular screening, tissue ...
Jan W, Buikema, Peter-Paul M, Zwetsloot, Pieter A, Doevendans, Joost P G, Sluijter, Ibrahim J, Domian   +4 more
openaire   +2 more sources

AP-1 is a component of the transcriptional network regulated by GSK-3 in quiescent cells. [PDF]

PLoS ONE, 2011
The protein kinase GSK-3 is constitutively active in quiescent cells in the absence of growth factor signaling. Previously, we identified a set of genes that required GSK-3 to maintain their repression during quiescence.
John W Tullai, Silvia Tacheva, Laura J Owens, Julie R Graham, Geoffrey M Cooper   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Neurotensin Phosphorylates GSK-3α/β through the Activation of PKC in Human Colon Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2006
Neurotensin (NT), a gastrointestinal hormone, binds its receptor [neurotensin receptor (NTR)] to regulate the growth of normal and neoplastic intestinal cells; molecular mechanisms remain largely undefined.
Qingding Wang, Yuning Zhou, B. Mark Evers   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

GSK-3 and Wnt signaling in neurogenesis and bipolar disorder

Frontiers in Molecular Neuroscience, 2012
The Wnt signaling pathway is critical for development of the mammalian central nervous system and regulates diverse processes throughout adulthood, including adult neurogenesis. Glycogen Synthase Kinase-3 (GSK-3) antagonizes the Wnt pathway and therefore
Alexander J Valvezan, Peter S Klein, Peter S Klein   +2 more
doaj   +1 more source

GSK-3beta is required for memory reconsolidation in adult brain. [PDF]

PLoS ONE, 2008
Activation of GSK-3beta is presumed to be involved in various neurodegenerative diseases, including Alzheimer's disease (AD), which is characterized by memory disturbances during early stages of the disease.
Tetsuya Kimura, Shunji Yamashita, Shinobu Nakao, Jung-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima   +8 more
doaj   +1 more source

GSK-3 and lysosomes meet in Alzheimer’s disease [PDF]

Communicative & Integrative Biology, 2013
Aberrant regulation of glycogen synthase kinase-3 (GSK-3) is implicated in Alzheimer's disease (AD), but the mechanisms involved remain elusive. Our recent study shows that GSK-3 impairs lysosomal acidification and that inhibition of GSK-3 re-acidified lysosomes in brains of AD mice.
Avrahami, Limor, Eldar-Finkelman, Hagit
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase

Frontiers in Molecular Neuroscience, 2012
Glycogen synthase kinase 3 (GSK-3) is an evolutionarily conserved multifaceted ubiquitous enzyme. In the central nervous system (CNS), GSK-3 acts through an intricate network of intracellular signaling pathways culminating in a highly divergent cascade ...
Norelle Christine Wildburger, Norelle Christine Wildburger, Norelle Christine Wildburger, Fernanda eLaezza, Fernanda eLaezza, Fernanda eLaezza   +5 more
doaj   +1 more source