Results 31 to 40 of about 16,343,665 (315)

GSK-3 – at the crossroads of cell death and survival [PDF]

Journal of Cell Science, 2014
ABSTRACT Glycogen synthase kinase 3 (GSK-3) is involved in various signaling pathways controlling metabolism, differentiation and immunity, as well as cell death and survival. GSK-3 targets transcription factors, regulates the activity of metabolic and signaling enzymes, and controls the half-life of proteins by earmarking them for ...
U. Maurer, F. Preiss, P. Brauns-Schubert, L. Schlicher, C. Charvet   +4 more
semanticscholar   +5 more sources

Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres

Image Analysis and Stereology, 2020
Glycogen synthase kinase 3 (GSK-3) plays an important role in metabolic regulation in skeletal muscles, and both insulin and adrenaline stimulate GSK-3 phosphorylation. The aim of the present study was to study the effect of insulin and adrenaline on GSK-
Katja Fink, Mateja Lobe Prebil, Nina Vardjan, Jorgen Jensen, Robert Zorec, Marko Kreft   +5 more
doaj   +1 more source

GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

Frontiers in Immunology, 2020
The SARS-CoV2 (COVID-19) pandemic and uncertainties in developing a vaccine have created an urgent need for new therapeutic approaches. A key question is whether it is possible to make rational predictions of new therapies based on the presently ...
C. Rudd
semanticscholar   +1 more source

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016–2019)

Expert Opinion on Therapeutic Patents, 2020
Introduction Glycogen synthase kinase 3 (GSK-3) is a constitutively active, ubiquitous expressed ser/thr kinase that is involved in a large number of signaling pathways.
Carlos Roca, N. Campillo
semanticscholar   +1 more source

GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals

Cells, 2021
Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between ...
Stephen L. Abrams, Shaw M. Akula, Akshaya K. Meher, Linda S. Steelman, Agnieszka Gizak, Przemysław Duda, Dariusz Rakus, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Giuseppe Montalto, Melchiorre Cervello, Peter Ruvolo, Massimo Libra, Luca Falzone, Saverio Candido, James A. McCubrey   +16 more
doaj   +1 more source

GSK-3 inhibitors for Alzheimer’s disease

Expert Review of Neurotherapeutics, 2007
Glycogen synthase kinase (GSK)-3 has been proposed as the link between the two histopathological hallmarks of Alzheimer's disease, the extracellular senile plaques made of beta-amyloid and the intracellular neurofibrillary tangles made of hyperphosphorylated tau.
Ávila, Jesús, Hernández, Félix
openaire   +3 more sources

Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways

Frontiers in Endocrinology, 2014
Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular ...
Colleen M Bartman, Jennifer eEgelston, Sravya eKattula, Leigh C Zeidner, Anthony eD'Ippolito, Bradley W Doble, Christopher J Phiel   +6 more
doaj   +1 more source

GSK-3 and lysosomes meet in Alzheimer’s disease [PDF]

Communicative & Integrative Biology, 2013
Aberrant regulation of glycogen synthase kinase-3 (GSK-3) is implicated in Alzheimer's disease (AD), but the mechanisms involved remain elusive. Our recent study shows that GSK-3 impairs lysosomal acidification and that inhibition of GSK-3 re-acidified lysosomes in brains of AD mice.
Hagit Eldar-Finkelman, Limor Avrahami
openaire   +3 more sources

Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death

BMC Cancer, 2010
Background Glycogen Synthase Kinase-3 (GSK-3) α and β are two serine-threonine kinases controlling insulin, Wnt/β-catenin, NF-κB signaling and other cancer-associated transduction pathways.
Colpo Anna, Pavan Laura, Montini Barbara, Tubi Laura, Manni Sabrina, Piazza Francesco, Gnoato Marianna, Cabrelle Anna, Adami Fausto, Zambello Renato, Trentin Livio, Gurrieri Carmela, Semenzato Gianpietro   +12 more
doaj   +1 more source

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

eNeuro, 2017
It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in Alzheimer’s disease (AD), yet little is known about the contribution of APP to intracellular signaling ...
Lisa Kirouac, Alexander J. Rajic, D. Cribbs, J. Padmanabhan   +3 more
semanticscholar   +1 more source