Results 41 to 50 of about 16,343,665 (315)
GSK-3: functional insights from cell biology and animal models
Frontiers in Molecular Neuroscience, 2011 Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related proteins: GSK-3α and GSK-3β.
Oksana eKaidanovich-Beilin +1 more
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Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases
Oxidative Medicine and Cellular Longevity, 2017 GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3α and GSK-3β isoforms, both active under basal conditions and inactivated upon phosphorylation by different upstream kinases.
R. Mancinelli +8 more
semanticscholar +1 more source
Focusing the spotlight on GSK-3 in aging
Aging, 2013 Aging/senescence occurs at both the level of the whole organism and the individual cell. Organismal aging is usually defined as the progressive loss of function accompanied by decreasing fertility and increasing mortality with advancing age [1]. Cellular senescence refers to the permanent arrest of cell division, which is characterized by several ...
Thomas Force, Jibin Zhou
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Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent. [PDF]
PLoS ONE, 2013 Glycogen synthase kinase-3 (GSK-3) inhibitors have been postulated as useful therapeutic tools for the treatment of chronic neurodegenerative and neuropsychiatric diseases.
Raquel Gómez-Sintes, José J Lucas
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GSK-3 in liver diseases: Friend or foe?
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 Liver diseases, including hepatitis due to hepatitis B or C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma pose major challenges for overall health due to limited curative treatment options. Thus, there is an urgent need to develop new therapeutic strategies for the treatment of these diseases.
Emma MR +6 more
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Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
Theranostics, 2016 Glycogen synthase kinase-3 (GSK-3) is associated with various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication ...
M. Pandey, T. DeGrado
semanticscholar +1 more source
Scientific Reports, 2018 Alzheimer’s disease (AD) is a neurodegenerative disease that is the leading cause of age-related dementia. Currently, therapeutic agent delivery to the CNS is a valued approach for AD therapy. Unfortunately, the CNS penetration is greatly hampered by the
Po-Hung Hsu +6 more
semanticscholar +1 more source
GSK-3beta is required for memory reconsolidation in adult brain. [PDF]
PLoS ONE, 2008 Activation of GSK-3beta is presumed to be involved in various neurodegenerative diseases, including Alzheimer's disease (AD), which is characterized by memory disturbances during early stages of the disease.
Tetsuya Kimura +8 more
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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
OncoTarget, 2016 Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory
J. McCubrey +18 more
semanticscholar +1 more source
AP-1 is a component of the transcriptional network regulated by GSK-3 in quiescent cells. [PDF]
PLoS ONE, 2011 The protein kinase GSK-3 is constitutively active in quiescent cells in the absence of growth factor signaling. Previously, we identified a set of genes that required GSK-3 to maintain their repression during quiescence.
John W Tullai +4 more
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