Results 51 to 60 of about 16,343,665 (315)

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Circulation Research, 2016
RATIONALE Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important
Jibin Zhou, F. Ahmad, S. Parikh, Nichole E. Hoffman, S. Rajan, V. Verma, Jianliang Song, Ancai Yuan, S. Shanmughapriya, Yuanjun Guo, E. Gao, W. Koch, J. Woodgett, M. Madesh, R. Kishore, Hind Lal, T. Force   +16 more
semanticscholar   +1 more source

Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery.

Journal of Medicinal Chemistry, 2019
Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective and brain penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase kinase-
V. Bernard-Gauthier, Andrew V. Mossine, Ashley C Knight, D. Patnaik, Wen-Ning Zhao, Chialin Cheng, Hema S. Krishnan, Lucius Lynn Zhao Xuan, Peter S. Chindavong, Surya A. Reis, J. Chen, X. Shao, J. Stauff, Janna Arteaga, P. Sherman, N. Salem, D. Bonsall, Brenda Amaral, Cassis Varlow, Lisa Wells, L. Martarello, Shil Patel, Steven H. Liang, R. Kurumbail, S. Haggarty, P. Scott, N. Vasdev   +26 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Functions of GSK-3 Signaling in Development of the Nervous System [PDF]

Frontiers in Molecular Neuroscience, 2011
Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development.
William D. Snider, Woo Yang Kim
openaire   +4 more sources

Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase

Frontiers in Molecular Neuroscience, 2012
Glycogen synthase kinase 3 (GSK-3) is an evolutionarily conserved multifaceted ubiquitous enzyme. In the central nervous system (CNS), GSK-3 acts through an intricate network of intracellular signaling pathways culminating in a highly divergent cascade ...
Norelle Christine Wildburger, Norelle Christine Wildburger, Norelle Christine Wildburger, Fernanda eLaezza, Fernanda eLaezza, Fernanda eLaezza   +5 more
doaj   +1 more source

Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. [PDF]

PLoS ONE, 2011
BACKGROUND: Traumatic brain injury (TBI) sets in motion cascades of biochemical changes that result in delayed cell death and altered neuronal architecture.
Pramod K Dash, Daniel Johnson, Jordan Clark, Sara A Orsi, Min Zhang, Jing Zhao, Raymond J Grill, Anthony N Moore, Shibani Pati   +8 more
doaj   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

GSK-3β Regulates the Expression of P21 to Promote the Progression of Chordoma

Cancer Management and Research, 2021
Li Chen,1,2 Yi Zuo,2 Ru Pan,2 Zhen Ye,1,2 Kailun Wei,1,2 Shaohuai Xia,1 Wencai Li,1 Jie Tan,2 Xuewei Xia1,2 1Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, People’s Republic of China; 2Guangxi ...
Chen L, Zuo Y, Pan R, Ye Z, Wei K, Xia S, Li W, Tan J, Xia X   +8 more
doaj  

Neurotensin Phosphorylates GSK-3α/β through the Activation of PKC in Human Colon Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2006
Neurotensin (NT), a gastrointestinal hormone, binds its receptor [neurotensin receptor (NTR)] to regulate the growth of normal and neoplastic intestinal cells; molecular mechanisms remain largely undefined.
Qingding Wang, Yuning Zhou, B. Mark Evers   +2 more
doaj   +1 more source