Results 61 to 70 of about 16,343,665 (315)

Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells

Journal of Biological Chemistry, 2018
Glycogen synthase kinase-3 (GSK-3) activity regulates multiple signal transduction pathways and is also a key component of the network responsible for maintaining stem cell pluripotency.
Kelsie J Faulds, Jennifer N Egelston, Laura J. Sedivy, M. Mitchell, Sanjana Garimella, Hanna Kozlowski, A. D’Alessandro, K. Hansen, Jeremy L. Balsbaugh, C. Phiel   +9 more
semanticscholar   +1 more source

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14–18, 24–26, 30–32, 34–36, and 38–40 weeks), stored at −80°C, and evaluated for serum levels ...
Nilson R. de Jesús, Guilherme R. de Jesús, Marcela I. Lacerda, Flávia C. dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S. F. Coutinho, Evandro M. Klumb   +7 more
wiley   +1 more source

Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration

Cardiovascular Research, 2018
With an estimated 38 million current patients, heart failure (HF) is a leading cause of morbidity and mortality worldwide. Although the aetiology differs, HF is largely a disease of cardiomyocyte (CM) death or dysfunction.
A. Singh, P. Umbarkar, Yuanjun Guo, T. Force, M. Gupte, Hind Lal   +5 more
semanticscholar   +1 more source

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity

Cells, 2020
Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure. Thus, there is an urgent need to understand the molecular mechanism of obesity-associated cardiac dysfunction.
Manisha Gupte, Prachi Umbarkar, Anand Prakash Singh, Qinkun Zhang, Sultan Tousif, Hind Lal   +5 more
doaj   +1 more source

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.

ACS Chemical Neuroscience, 2018
In view of the clinical need for new antiseizure drugs (ASDs) with novel modes of action, we used a zebrafish seizure model to screen the anticonvulsant activity of medicinal plants used by traditional healers in the Congo for the treatment of epilepsy ...
Najat Aourz, A. Serruys, J. Chabwine, P. B. Balegamire, T. Afrikanova, R. Edrada-Ebel, A. Grey, A. Kamuhabwa, L. Walrave, Camila V. Esguerra, F. van Leuven, P. D. de Witte, I. Smolders, A. Crawford   +13 more
semanticscholar   +1 more source

Screening for Social Determinants of Health in Patients with Systemic Lupus Erythematosus: A Point‐of‐Care Feasibility Study

Arthritis Care &Research, Accepted Article.
Objectives Social determinants of health (SDoH) can impact outcomes but are not routinely screened for in US outpatient rheumatology clinics. This study determined the feasibility of routine point‐of‐care SDoH screening among patients with systemic lupus erythematosus (SLE), and associated barriers and facilitators at the physician, care team, and ...
S. Sam Lim, Vijay R. Nadipelli, Michelle Bruno, Daphne Lew, Bernard Rubin, Charmayne M. Dunlop‐Thomas, Kelsey Hulcher, Kristi R. Mitchell, Lydia Demetriou, Jeff Berko, Jason Bao, Alfred H.J. Kim   +11 more
wiley   +1 more source

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

iScience, 2021
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth.
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor   +6 more
doaj  

GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma

Development, 2019
Cerebellar development requires regulated proliferation of cerebellar granule neuron progenitors (CGNPs). Inadequate CGNP proliferation causes cerebellar hypoplasia whereas excessive CGNP proliferation can cause medulloblastoma, the most common malignant
J. Ocasio, Rolf Dale P Bates, Carolyn D Rapp, T. Gershon   +3 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source