Results 61 to 70 of about 121,769 (336)

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

GSK-3β Regulates the Expression of P21 to Promote the Progression of Chordoma

Cancer Management and Research, 2021
Li Chen,1,2 Yi Zuo,2 Ru Pan,2 Zhen Ye,1,2 Kailun Wei,1,2 Shaohuai Xia,1 Wencai Li,1 Jie Tan,2 Xuewei Xia1,2 1Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, People’s Republic of China; 2Guangxi ...
Chen L, Zuo Y, Pan R, Ye Z, Wei K, Xia S, Li W, Tan J, Xia X   +8 more
doaj  

GSK-3-Mediated Phosphorylation Enhances Maf-Transforming Activity [PDF]

Molecular Cell, 2007
The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 ...
Rocques, Nathalie, Abou Zeid, Nancy, Sii-Felice, Karine, Lecoin, Laure, Felder-Schmittbuhl, Marie-Paule, Eychène, Alain, Pouponnot, Celio   +6 more
openaire   +2 more sources

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

eLife, 2014
Glycogen synthase kinase-3 (GSK-3) is a key regulator of many cellular signaling pathways. Unlike most kinases, GSK-3 is controlled by inhibition rather than by specific activation.
Jennifer L Stamos, Matthew Ling-Hon Chu, Michael D Enos, Niket Shah, William I Weis   +4 more
doaj   +1 more source

Histone Acetylation-Mediated Regulation of the Hippo Pathway [PDF]

, 2013
The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment.
A Rebbaa, A Salic, Abdelhadi Rebbaa, Ali J. Marian, B Zhao, B Zhao, BL Mirkin, BR Mardin, BS Robinson, C Alarcon, C Zhang, CA Thorne, D Basu, D Lai, Dipanjan Basu, E Miller, E Pazolli, F Chu, F Kanai, F Martin-Belmonte, FA Grusche, FX Yu, G Halder, H Oh, H Oh, HH Cho, HJ Chen, HM Prince, I Lian, J Avruch, J Zhang, JP Lyons, K Harvey, KF Harvey, KF Harvey, L Azzolin, L Zender, L Zhao, LM McCaffrey, M Cordenonsi, M Sudol, MA St John, Miguel Reyes-Múgica, NA Grzeschik, QY Lei, RS Udan, S Wu, SA Mousa, T de Cristofaro, T Xu, W Huang, WM Konsavage Jr, X Varelas, X Varelas, XJ Li, Y Hao, Y Liu, Y Wang, Z Zhou   +58 more
core   +3 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity

Cells, 2020
Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure. Thus, there is an urgent need to understand the molecular mechanism of obesity-associated cardiac dysfunction.
Manisha Gupte, Prachi Umbarkar, Anand Prakash Singh, Qinkun Zhang, Sultan Tousif, Hind Lal   +5 more
doaj   +1 more source

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

Arthritis Care &Research, EarlyView.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie, Michael P. Fisher, Kristen Backor, Hannah Tyldsley, Ashira Blazer, Candace Feldman, Andrea Knight, S. Sam Lim, Barbara Ann Polk, Ed Yelin, Edith Williams, Karen H. Costenbader   +11 more
wiley   +1 more source

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources