Results 71 to 80 of about 121,769 (336)

Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation. [PDF]

PLoS ONE, 2011
Over-activity and elevated expression of glycogen synthase kinase-3 (GSK-3) has been implicated in the etiology of insulin resistance and Type 2 diabetes.
Satish Patel, Katrina Macaulay, James R Woodgett   +2 more
doaj   +1 more source

GSK3 inhibition reduces inflammatory responses of microglia and upregulates Il-10 production [PDF]

, 2017
Introduction: Neurodegeneration resulting from pathogen invasion or tissue damage has been associated with activation of microglia, and exacerbated by the release of neurotoxic mediators such as pro-inflammatory cytokines, chemokines and reactive oxygen ...
Hassan, Masriana, Md Zain, Zuhaida, Vidyadaran, Sharmili   +2 more
core  

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac [PDF]

, 2009
Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance of cell movements during gastrulation, and the induction of cell polarity.
Burkart, K, Cabello, J, Charette, S J, Günesdogan, U, Hengartner, M O, Lochnit, G, Neukomm, L J, Schnabel, R   +7 more
core   +5 more sources

Prevalence, Determinants, and Outcomes of Low Disease Activity and Remission Attainment in Patients With Systemic Lupus Erythematosus That Is Clinically Active

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify in patients with systemic lupus erythematosus (SLE) with clinically active disease the attainment of frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) and the frequency and determinants of flare and damage accrual after target attainment.
Yanjie Hao, Dylan Hansen, Rangi Kandane‐Rathnayake, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Kristine (Pek Ling) Ng, Annie Law, B. M. D. B. Basnayake, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Naoaki Ohkubo, Yoshiya Tanaka, Shirley Chan, C. S. Lau, Vera Golder, Alberta Hoi, Shereen Oon, Eric Morand, Mandana Nikpour, for the Asia‐Pacific Lupus Collaboration   +39 more
wiley   +1 more source

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) network investigators   +14 more
wiley   +1 more source

Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin [PDF]

, 2015
Autophagy is a lysosomal catabolic route for protein aggregates and damaged organelles which in different stress conditions, such as starvation, generally improves cell survival.
Catizone, Angiolina, De Vito, S, Fabrizi, C, Fornai, F, Fumagalli, Lorenzo, Lenzi, P, Pompili, Elena, Ricci, G, Somma, Francesca   +8 more
core   +2 more sources

Design and Prototyping of Topology‐Optimized, Additively Manufactured Lightweight Components for Space Robotic Systems: A Case Study

Advanced Engineering Materials, EarlyView.
The results demonstrate a simulation‐driven workflow that applies LSB topology optimization with additive manufacturing constraints to mission‐specific load cases, integrating European Cooperation for Space Standardization compliant verification and manufacturability to develop structurally efficient rover suspension components.
Stelios K. Georgantzinos, Grigorios Kostopoulos, Eleni Papadopoulou, Stefanos Voulgaris, Alexandra Tseni, Panteleimon Bakalis, Maria N. Gkara, Chara Ch. Mitropoulou, Georgios Kazakis, Alin Munteanu, Jeremi Gancet, Nikos D. Lagaros   +11 more
wiley   +1 more source

Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells

Biology Direct, 2011
Background Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine (Ser/Thr) kinase comprising two isoforms, GSK-3α and GSK-3β. Both enzymes are similarly inactivated by serine phosphorylation (GSK-3α at Ser21 and GSK-3β at Ser9 ...
Kypta Robert M, Campa Victor M
doaj   +1 more source

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib

Frontiers in Molecular Neuroscience, 2020
Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD).
Junyu Li, Junyu Li, Shanshan Ma, Shanshan Ma, Jingnan Chen, Kunhua Hu, Kunhua Hu, Yongyi Li, Yongyi Li, Zeyu Zhang, Zeyu Zhang, Zixiang Su, Zixiang Su, James R. Woodgett, Mingtao Li, Mingtao Li, Qiaoying Huang, Qiaoying Huang   +17 more
doaj   +1 more source