Results 81 to 90 of about 121,769 (336)
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. [PDF]
, 2013 Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF(Cdc4).
Diedrich, Jolene K +4 more
core +1 more source
Deconstructing GSK‐3: The Fine Regulation of Its Activity [PDF]
International Journal of Alzheimer’s Disease, 2011 Glycogen synthase kinase‐3 (GSK‐3) unique position in modulating the function of a diverse series of proteins in combination with its association with a wide variety of human disorders has attracted significant attention to the protein both as a therapeutic target and as a means to understand the molecular basis of these disorders.
Medina, Miguel, Wandosell, Francisco
openaire +3 more sources
Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
Advanced Functional Materials, EarlyView.This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Novel reporter alleles of GSK-3α and GSK-3β.
PLoS ONE, 2012 Glycogen Synthase Kinase 3 (GSK-3) is a key player in development, physiology and disease. Because of this, GSK-3 inhibitors are increasingly being explored for a variety of applications. In addition most analyses focus on GSK-3β and overlook the closely
William B Barrell +2 more
doaj +1 more source
Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes [PDF]
, 2011 Patients with diabetes are at higher risk of stroke and experience increased morbidity and mortality after stroke. We hypothesized that cortical neurons develop insulin resistance, which decreases neuroprotection via circulating insulin and insulin-like ...
Bhumsoo Kim +6 more
core +2 more sources
Neuronal Polarity: Until GSK-3 Do Us Part [PDF]
Current Biology, 2005 Specification of the axon and dendrites is a critical step in the development of a neuron. Two new studies have shed light on the molecular pathway that controls the establishment of neuronal polarity.
openaire +2 more sources
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins [PDF]
Chemistry & Biology, 2003 Gastropod mollusks have been used for over 2500 years to produce the "Tyrian purple" dye made famous by the Phoenicians. This dye is constituted of mixed bromine-substituted indigo and indirubin isomers. Among these, the new natural product 6-bromoindirubin and its synthetic, cell-permeable derivative, 6-bromoindirubin-3'-oxime (BIO), display ...
Meijer, L. +15 more
openaire +4 more sources
Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling
Advanced Healthcare Materials, EarlyView.A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl +8 more
wiley +1 more source
Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation [PDF]
, 2017 Connexins are a large family of proteins that form gap junction channels allowing exchange of ions and small metabolites between neighboring cells. They have been implicated in pathological processes such as tumourigenesis in which they may act as tumour
Burnier, Laurent +9 more
core
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]
, 2019 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J. +2 more
core +3 more sources