Results 101 to 110 of about 46,501 (160)

Inhibition of GSK3β Modulates Cell Death in Epithelial Ovarian Cancer

, 2016
Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually.
Pathak, Naeha, Walther, Tyler, Cutter, Noelle   +2 more
core   +1 more source

Identification and sequence of multiple alternative transcripts of goat GSK3β.

, 2014
We sequence more than 100 positive clones to identify the multiple GSK3β transcripts. Six variant transcripts of GSK3β have been shown in the picture.
Yan Wang (15435), Hongping Zhang (152549), Tao Zhong (501589), Linjie Wang (152532), Li Li (14993), Yuguo Hou (644884), Yilin Wang (490921)   +6 more
core   +1 more source

GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation

, 2015
The role of Hedgehog-Gli (Hh-Gli) signaling in colon cancer tumorigenesis has not yet been completely elucidated. Here we provide strong evidence of Hh-Gli signaling involvement in survival of colon cancer cells, with the main trigger of activation being
Ozretić, Petar, Levanat, Sonja, Trnski, Diana, Ramić, Snježana, Musani, Vesna, Martinić, Marina, Sabol, Maja, Gojević, Ante   +7 more
core   +1 more source

Activated GSK3β is involved in Sirt2 stable knockdown ESC differentiation.

, 2013
(A) Western blots analyzing pGSK3β and total GSK3β levels in control (shpLKO.1) and Sirt2 knockdown cells (shSirt2-1) using GAPDH as a loading control. (B) The relative protein levels of pGSK3β and total GSK3β levels in GSK3β mutant cell lines.
Wen Chen (30046), Xiaoxing Si (421737), Xudong Guo (153535), Long Chen (315739), Yanxin Xu (474254), Jiuhong Kang (153524), Guiying Wang (153514)   +6 more
core   +1 more source

Glycogen Synthase Kinase-3 Beta (GSK3β) as a Potential Drug Target in Regulating Osteoclastogenesis: An Updated Review on Current Evidence

Biomolecules
Glycogen synthase kinase 3-beta (GSK3β) is a highly conserved protein kinase originally involved in glucose metabolism, insulin activity, and energy homeostasis.
Sok Kuan Wong
doaj   +1 more source

The functional study of GSK3β in TLR3 signaling

, 2015
Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is critical for the production of inflammatory cytokines in various Toll-like receptor (TLR)-mediated signaling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses.
고려진
core  

The effects of GSK3β knockout on the morphology of the nucleolus.

, 2014
(A) The size and number of nucleoli in GSK3β+/+ and GSK3β−/− MEFs were analyzed in double-stained preparations using anti-UBF (red) and anti-nucleolin (green) antibodies as nucleolar markers. (B) Quantitative evaluation of the number of nucleoli per cell.
Anne Von Euler (573528), Piergiorgio Percipalle (393101), Laura Borgonovo-Brandter (573527), Neus Visa (245920), Douglas Lamont (573529), Bader Al-Muzzaini (393098), Martin Corcoran (573526), Aishe A. Sarshad (573525)   +7 more
core   +1 more source

RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline and loss of neuronal integrity. Emerging evidence suggests that RhoA, Rho-associated coiled-coil kinase (ROCK), and their downstream effector molecule ...
Jayden E. Yon, Milan M. Medd, Hongxin Dong   +2 more
core   +1 more source

Retraction: In silico investigation of novel Plasmodium Falciparum glycogen synthase kinase (pfGSk3β) inhibitors for the treatment of malaria infection. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins. [PDF]

NPJ Biosens
Zargarbashi S, Dominguez C, Peters M, Yousefi A, Munday S, Wang Y, Chatterjee S, Hudson AJ, Gordon R, Mellor CJ, Xu L, Rahmani M, Ying C.   +12 more
europepmc   +1 more source