Results 121 to 130 of about 70,328 (289)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Breast Cancer Research, 2019
Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive.
G. Vijay, N. Zhao, P. den Hollander, M. Toneff, R. Joseph, M. Pietila, J. Taube, T. R. Sarkar, E. Ramirez-Peña, S. Werden, M. Shariati, Ruli Gao, Mary Sobieski, C. Stephan, N. Sphyris, N. Miura, P. Davies, Jeffrey T. Chang, R. Soundararajan, J. Rosen, Sendurai A Mani   +20 more
semanticscholar   +1 more source

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

Science Translational Medicine, 2020
Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ. The noradrenergic link Norepinephrine (NE) and the noradrenergic system play a main role in cognition and noradrenergic changes have been documented in patients with ...
Fa-Xiang Zhang, M. Gannon, Yunjia Chen, Shun Yan, Sixue Zhang, Wendy Feng, Jiahui Tao, Bingdong Sha, Zhenghui Liu, Takashi Saito, T. Saido, C. Keene, Kai Jiao, Erik D. Roberson, Huaxi Xu, Qin Wang   +15 more
semanticscholar   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility

Pharmacogenomics and Personalized Medicine, 2020
Bingqi Wang, Min Wang, Xianping Li, Min Yang, Lei Liu Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, People’s Republic of ChinaCorrespondence: Min WangDepartment of Laboratory ...
Wang B, Wang M, Li X, Yang M, Liu L
doaj  

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

Cell Death and Disease, 2022
NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL cells are not completely understood.
Filomena De Falco, Chiara Rompietti, Daniele Sorcini, Angela Esposito, Annarita Scialdone, Stefano Baldoni, Beatrice Del Papa, Francesco Maria Adamo, Estevão Carlos Silva Barcelos, Erica Dorillo, Arianna Stella, Mauro Di Ianni, Isabella Screpanti, Paolo Sportoletti, Emanuela Rosati   +14 more
doaj   +1 more source

Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone [PDF]

, 2019
In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discrimination ...
Biagioni, Stefano, Cacci, Emanuele, Gioia, Roberta, Lupo, Giuseppe, Nisi, PAOLA SERENA   +4 more
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder. [PDF]

, 2017
Autism spectrum disorder (ASD) is a behaviorally defined disorder affecting 1 in 68 children. Currently, there is no known cause for the majority of ASD cases nor are there physiological diagnostic tools or biomarkers to aid behavioral diagnosis.
Ashwood, Paul, Onore, Charity, Van de Water, Judy, Yang, Houa   +3 more
core   +1 more source