Results 141 to 150 of about 187,197 (244)

Overshooting of Hypoplastic Models With Intergranular Strain: Manifestation, Implications and Remedy

International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT Intergranular strain extensions of hypoplasticity (IGS, ISA, GIS) are widely used to model small‐strain and cyclic soil behaviour. However, recent studies and our own simulations reveal that these models can exhibit stress overshooting not only under repeated small loading cycles but also during monotonic loading.
Jan Machaček, Merita Tafili, Carlos Grandas Tavera   +2 more
wiley   +1 more source

Computational insights on the molecular interplay between KRas (G12D mutation) and SOS1 modulated by the inhibitor BI-3406. [PDF]

PLoS Comput Biol
Zeng J, Lan Y, Xia F.
europepmc   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications. [PDF]

Protein Sci
Srinivasu BY, Damerla TS, Stec A, Zhou Z, Engen JR, Westover KD, Wales TE.   +6 more
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

A Case of Acalculous Cholecystitis During Lenvatinib Plus Pembrolizumab Therapy for Advanced Renal Cell Carcinoma. [PDF]

IJU Case Rep
Soga E, Noguchi G, Kobayashi K, Shibata R, Jikuya R, Tatenuma T, Komeya M, Ito H, Hasumi H, Makiyama K.   +9 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity. [PDF]

Nature
Vo AA, Modak A, Lu S, Blanchard SC, Lambert NA, Robertson MJ.   +5 more
europepmc   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Protective effects of three natural extracts on ovalbumin-induced intestinal and skin damage in felines via the gut-skin axis: An <i>in vitro</i> study. [PDF]

Biochem Biophys Rep
Wang H, Liu T, Bai H, Jin H, Wang Z.
europepmc   +1 more source