Results 131 to 140 of about 187,197 (244)

Long‐Term Outcomes and Predictors of Delayed Steroid Initiation in Type 1 Autoimmune Pancreatitis Initially Managed Without Corticosteroids

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Although type 1 autoimmune pancreatitis (AIP) responds well to corticosteroids, spontaneous remission can also occur. This study evaluated long‐term outcomes and predictors of delayed steroid initiation in AIP patients initially managed conservatively.
Yasuhiro Kuraishi, Akira Nakamura, Masafumi Minamisawa, Takumi Yanagisawa, Chinatsu Yonekura, Nobukazu Sasaki, Shunsuke Imamura, Takefumi Kimura, Yugo Iwaya, Tadanobu Nagaya   +9 more
wiley   +1 more source

The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation. [PDF]

Mol Cell Proteomics
Zhu J, Li W, Ji M, Chang X, Cao Y, Gao J, Qi S, Kong E.   +7 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions. [PDF]

Inflammation
Dib K.
europepmc   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Observing intersubunit dynamics in single yeast ribosomes. [PDF]

Nucleic Acids Res
Das A, Grove AK, Ivanov AV, Wakabayashi H, Ermolenko DN.   +4 more
europepmc   +1 more source

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source

Corrigendum to "Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling" [Mol. Cells 49 (2026) 100342]. [PDF]

Mol Cells
Kim JH, Seong S, Kim K, Kim I, Koh JT, Kim N.   +5 more
europepmc   +1 more source

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass. [PDF]

Biochem J
Simanshu DK, McCormick F.
europepmc   +1 more source