Results 111 to 120 of about 222,027 (284)
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
Going in GTP cycles in the nucleolus [PDF]
The Journal of Cell Biology, 2005 Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways.
openaire +2 more sources
OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice
Advanced Science, EarlyView.OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang +17 more
wiley +1 more source
Effect of Adding Green Tea Polyphenols to Bali Bull Spermatozoa Diluent: Implications for Semen Quality, Hydrogen Peroxide Concentration, and Fertilization Rate [PDF]
Journal of Global Innovations in Agricultural SciencesGreen Tea Polyphenols (GTP) are bioactive compounds found in green tea and are known to have strong antioxidant properties. This study aims to determine the effectiveness of adding GTP in the extender in terms of quality, hydrogen peroxide (H2O2 ...
Yuni Sartika, Herry Sonjaya
doaj +1 more source
Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
Targeted Quantitative Profiling of GTP-Binding Proteins in Cancer Cells Using Isotope-Coded GTP Probes [PDF]
, 2018 GTP-binding proteins play important roles in many essential biological processes, including cell signaling, trafficking, and protein synthesis. To assess quantitatively these proteins at the whole proteome level, we developed a high-throughput targeted ...
Rong Cai (412492) +8 more
core +1 more source
A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability
Advanced Science, EarlyView.The Tri‐M (Multi‐recombinase, Multi‐recognition site, and Multi‐nested) sparse cellular labeling system, built upon competitive recombination, integrates transgenic mice with viral injection to achieve tunable and long‐term stable sparse labeling of specific cell types with region selectivity, from sparse populations to individual cells, facilitating ...
Xiaomei Tang +17 more
wiley +1 more source
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source
Advanced Science, EarlyView.SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu +13 more
wiley +1 more source
Kinetic analyses of GTP hydrolysis using indicated myrArf1•GTP.
(A) Time course of Arf GAP activity with high concentrations (5 nM) of ASAP1PZA using WT or [L8A/F13A]myrArf1•GTP as substrates. For these assays, myrArf1 was loaded with [α32P]GTP, ASAP1PZA was added, the reaction was quenched after the indicated ...
R. Andrew Byrd (2463943) +10 more
core +1 more source