Results 211 to 220 of about 339,556 (339)

Structural and biochemical basis of ROC-dependent activation of LRRK2. [PDF]

PNAS Nexus
Park Y, Wu C, Tennessen K, Wan L, Hoang NC, Hoang CW, Liao J, Hoang QQ.   +7 more
europepmc   +1 more source

Optical Kerr Gating as a Strategy for Noise Reduction in Femtosecond Stimulated Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
We report an experimental approach, where an Optical Kerr gate is incorporated with Femtosecond Stimulated Raman Spectrometry (FSRS). The gate functions as a temporal filter that preferentially suppresses the FSRS inherent background. FSRS spectra are reported with the Kerr‐gated methodology with significantly improved SNR compared to the conventional ...
Spyridon Kaziannis, Lazaros Varvarezos, Sotiris Danakas, Elissavet Karkadaki, Cesar Bernando, Miroslav Kloz   +5 more
wiley   +1 more source

Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. [PDF]

Cancer Res
Kamgar M, Hobbes GA, Davidson R, Dorbin D, Herrera J, Langenheim JF, Burge RA, Aldakkak M, Conrardy RD, Szabo A, Thalji SZ, Mayer B, Grahl JJ, Chung BY, Phan A, Thomas JP, Seo YD, Evans DB, Christians KK, Erickson B, Hall WA, George B, Tsai S, Lytle NK, Der CJ, Kurzrock R, McFall T.   +26 more
europepmc   +1 more source

GTP-CH Activity in Bovine Retina [PDF]

, 1990
L. Hanneken, G. Cremer-Bartels, H. Gerding, Kunibert Krause   +3 more
openalex   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Optimizing spatial organization of FtsZ rings for large-scale constriction in synthetic cells. [PDF]

Nat Commun
Panevska A, Šakanović A, Paccione G, Rivas G, Schwille P.   +4 more
europepmc   +1 more source

GTP‐cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP‐CH1 deficiency: Identification and functional characterization of four novel mutations

, 2004
Barbara Garavaglia, Federica Invernizzi, Maria Luigia Carbone, Valeria Viscardi, Francesca Saracino, Daniele Ghezzi, Massimo Zeviani, Giovanna Zorzi, Nardo Nardocci   +8 more
openalex   +2 more sources

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Impact of KRAS-G12 Mutations on the KRAS-GTP Bound Conformational Dynamics: Structure, Free Energy Barriers and Drugging Pockets. [PDF]

JACS Au
Hu Z, Sha Z, Martí J, Guo SJ, Tao SC.
europepmc   +1 more source

A GTP Analogue Induces Calcium Release but Not Secretion in Rat Mast Cells [PDF]

, 2009
Friederike von zur Mühlen, Reinhold Penner   +1 more
openalex   +1 more source