Results 281 to 290 of about 339,556 (339)

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application. [PDF]

Chembiochem
Fataeri M, Rosenthal K.
europepmc   +1 more source

Identification of aHighly Cooperative PROTAC DegraderTargeting GTP-Loaded KRAS(On) Alleles

Vesna Vetma (7953920), Ilaria Puoti (18965718), Natalia K. Karolak (22531394), Sohini Chakraborti (10736907), Emelyne Diers (2112991), Enrico Girardi (78640), Shakil Khan (22531397), Giorgia Kidd (18965715), Katrin G. Kropatsch (22531400), Ross Mclennan (22531403), Suzanne O’Connor (22531406), Matthias Samwer (19333201), Nicole Trainor (2094256), Claire Whitworth (323999), Andre J. Wijaya (22531409), Jeff Y. F. Wong (22531412), David Zollman (4751685), William Farnaby (2297479), Johannes Popow (6388691), Alessio Ciulli (762789), Peter Ettmayer (3013665), Kirsten McAulay (8921045)   +21 more
openalex   +1 more source

Sodium–glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial

Journal of Diabetes Investigation, EarlyView.
Combining oral sodium‐glucose cotransporter 2 inhibitors with reduced intravitreal injections of anti‐vascular endothelial growth factor showed potential efficacy for mild diabetic macular edema. ABSTRACT Aims To investigate the potential of sodium–glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular
Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote   +6 more
wiley   +1 more source

Termination of the integrated stress response. [PDF]

Science
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A.   +6 more
europepmc   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling. [PDF]

Proc Natl Acad Sci U S A
Chang TW, Lee FS.
europepmc   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

GTP release-selective agonists prolong opioid analgesic efficacy. [PDF]

Nature
Stahl EL, Swanson MA, Dang VQ, Cameron MD, Kennedy NM, Bannister TD, Bohn LM.   +6 more
europepmc   +1 more source

Molar–Incisor and Generalized Grade C Periodontitis: Distinct Microbiome–Immune Interactions Suggest Divergent Pathogenesis

Journal of Periodontal Research, EarlyView.
Molar–Incisor (PerioC‐MIP) and Generalized (PerioC‐G) Grade C Periodontitis in systemically healthy patients exhibit different microbiological, inflammatory markers, and genomic signatures, as the analysis of subgingival content from North Americans with PerioC‐MIP and Brazilians with PerioC‐G (geographic preference of each respective phenotype ...
Camila S. Stolf, Hélvis E. S. Paz, Murilo C. Paraluppi, Manuela M. V. Miguel, Mauro P. Santamaria, Mabelle F. Monteiro, Deyvid E. Amgarten, Raquel R. A. Franco, Luciana S. Branco‐de‐Almeida, Luciana M. Shaddox, Renato C. V. Casarin   +10 more
wiley   +1 more source

Extensile Active Hydrogels Driven by Living FtsZ Polymers. [PDF]

Small
Kharbedia M, Herráez-Aguilar D, Calero M, López-Menendez H, Luque-Rioja C, Moleiro LH, Santos C, Lillo P, Monroy F.   +8 more
europepmc   +1 more source