Results 261 to 270 of about 339,556 (339)

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

The Role of the TG2-GPR56 Complex in Cutaneous Squamous Cell Carcinoma (CSCC) Aggression and Therapeutic Resistance. [PDF]

Int J Mol Sci
Weber DJ, Cook ME, Yu W, Redondo M, Godoy-Ruiz R.   +4 more
europepmc   +1 more source

N-methyl-D-aspartate (NMDA) -evoked Ca2+ Mobilization via GTP-binding Proteins in Cultured Hippocampal Neurons

, 1994
Kunihiko Haráda, Haruhide Ito
openalex   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling. [PDF]

EMBO J
Cao H, Huang X, Jiang X, Deng J, Wang J, Wu C, Hu M, Zeng B, Hu Z, Pan H, Yang Y, Zheng K, Shen R, Zhang M, Liu B.   +14 more
europepmc   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Local Ras/actin signaling orients individual pseudopods in shallow gradients. [PDF]

Proc Natl Acad Sci U S A
van Haastert PJM.
europepmc   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Tubulin polymerization dynamics are influenced by magnetic isotope effects consistent with the radical pair mechanism. [PDF]

Sci Adv
Zadeh-Haghighi H, Siguenza CR, Smith RP, Simon C, Craddock TJA.   +4 more
europepmc   +1 more source

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang, Borja Martinez‐Tellez, Alida Kindt, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R. Ruiz, Lucas Jurado‐Fasoli   +7 more
wiley   +1 more source