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Trypanosomal MICOS Is Assembled on Non‐Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins

Molecular Microbiology, EarlyView.
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová, Teresa Wagner, Tomáš Bílý, Martina Tesařová, Corinna Benz, Hassan Hashimi   +5 more
wiley   +1 more source

Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma. [PDF]

Oncogene
Teertam SK, Singh MK, Altameemi S, Gude S, Roy S, Rossman RN, Newton MA, Bennett DD, Ahmad N, Cheng X, Setaluri V.   +10 more
europepmc   +1 more source

Association between circulating GTP cyclohydrolase 1 concentrations and acute ischemic stroke: an exploratory case-control study in a Chinese population. [PDF]

Front Neurol
Yuan S, Yang C, Yong PH, Ng ZX, Ren B, Li M, Wei G, Liang L.   +7 more
europepmc   +1 more source

KRAS G12R in pancreatic cancer: why this mutation resists current inhibitor strategies. [PDF]

Oncologist
Kern KA.
europepmc   +1 more source

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft. [PDF]

Neoplasia
González J, Cai X, Diao W, Roué G, València-Clua K, Olmo-González D, González-Cao M, Jain A, Jantus-Lewintre E, Giménez-Capitán A, Molina-Vila MA, Codony-Servat J, Cao P, Rosell R.   +13 more
europepmc   +1 more source

KRAS G12C-Targeted Therapy in Non-Small Cell Lung Cancer: From Resistant Salvage to Potential First-Line Backbone. [PDF]

Int J Mol Sci
Rosas D, Barad P, Wright J, Raez L.
europepmc   +1 more source

Precision Targeting of <i>KRAS</i>-Mutant Cancers: Beyond G12C Toward G12D and Pan-RAS Therapeutic Strategies. [PDF]

Int J Mol Sci
Kano Y.
europepmc   +1 more source

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Interaction of liver plasma membranes and GTP with GTP hydrolysis

Biochemical and Biophysical Research Communications, 1973
Abstract [ 14 C]GTP or a metabolic product of GTP binds to liver membranes. Less label was associated with membranes when membranes were incubated with increasing concentrations of carrier GTP; ATP did not displace the label. Chromatography of extracted incubation mixtures of [ 14 C]GTP and membranes revealed that over 96% of the nucleotide was ...
N I, Swislocki, S, Scheinberg, M, Sonenberg   +2 more
openaire   +2 more sources