Results 241 to 250 of about 339,556 (339)

Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer. [PDF]

Mol Cancer Ther
Price HE, Stauffer S, Lee H, Isanogle KA, Wu Y, Powell K, Baker A, Stauffer L, Perciaccante AJ, Jewell CP, Hernandez ER, Aljabri AK, Odeniyide P, Pratilas CA, Burgan W, Edmondson EF, Difilippantonio S, Kortum RL, Shern JF, Jenkins LM, Rossman KL, Yohe ME.   +21 more
europepmc   +1 more source

An investigation into the impact and effectiveness of beginning and early career primary teachers, trained on a work-based learning route, in the delivery of primary languages at Key Stage 2 [PDF]

, 2012
Dudley, Sally, Griffiths, Vivienne
core  

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

A Dual Luminescent and Chromogenic Pt-NCN Complex for the Detection of GTP and CTP in Aqueous Media. [PDF]

Inorg Chem
Valdes-García J, Vonlanthen M, Cuétara-Guadarrama F, Garcia-Bassoco D, Valdés-Negrín HL, López-Pérez A, Rivera E, Hernández-Ortega S, Dorazco-González A.   +8 more
europepmc   +1 more source

Elucidating conformational dynamics of GDP/GTP-KRAS complexes caused by mutations from the switch domain I through Gaussian accelerated molecular dynamics simulations

Shuhua Shi, Aijia Liu, Yutian Guo
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Large-scale optical trapping using a gradient-thickness protected microbottle resonator. [PDF]

Microsyst Nanoeng
Li Y, Wang H, Guo Z, Zhao X, Zhou Y, Wang Q, Luo M, Cai H, Chin LK, Liu AQ, Wu X.   +10 more
europepmc   +1 more source

Employment based initial teacher training : operational manual AY12/13 [PDF]

, 2012

core  

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

How interdiction of inositol pyrophosphate catabolism perturbs the fission yeast response to phosphate starvation. [PDF]

Nucleic Acids Res
Babor J, Sanchez AM, Prucker I, Jessen HJ, Schwer B, Shuman S.   +5 more
europepmc   +1 more source