Results 251 to 260 of about 339,556 (339)

1H, 13C, 15N, and 31P resonance assignments of the Q61R mutant of NRAS bound to GTP.

Alok K. Sharma
openalex   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Oligomerization-dependent and synergistic regulation of Cdc42 GTPase cycling by a GEF and a GAP. [PDF]

EMBO Rep
Tschirpke S, Daalman WK, van Opstal F, Laan L.   +3 more
europepmc   +1 more source

Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy

, 2017
Shota Matsunaga, Yuta Hano, Yuta Saito, Kazuhiro J. Fujimoto, Takashi Kumasaka, Shigeyuki Matsumoto, Tohru Kataoka, Fumi Shima, Shigenori Tanaka   +8 more
openalex   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

The ribosome derives the energy to translocate and unwind mRNA from EF-G binding. [PDF]

Nat Commun
Amiri H, Van Patten WJ, Rexroad G, Desai VP, Sterwerf BA, Lancaster L, Noller HF, Bustamante C.   +7 more
europepmc   +1 more source

Funding manual : employment-based initial teacher training : for academic year 2011/12 [PDF]

, 2011

core  

Signalling elements in higher plants: identification and molecular analysis of an auxin-binding-protein, GTP-binding regulatory proteins and calcium sensitive proteins

, 1989
Klaus Palme, Thomas Diefenthal, Thomas Hesse, Klaus Nitschke, Narciso Campos, Joachim Feldwisch, Christine Garbers, Friederike Hesse, Sybil Schwonke, Jeff Schell   +9 more
openalex   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Ran modulates allosteric crosstalk between importin β surfaces. [PDF]

Nat Commun
Ko YH, Li F, Suinn SS, Li J, Hou CD, Lokareddy RK, Cingolani G.   +6 more
europepmc   +1 more source