Results 51 to 60 of about 193,264 (147)

Molecular modeling study for interaction between Bacillus subtilis Obg and Nucleotides. [PDF]

PLoS ONE, 2010
The bacterial Obg proteins (Spo0B-associated GTP-binding protein) belong to the subfamily of P-loop GTPase proteins that contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain which is ...
Yuno Lee, Woo Young Bang, Songmi Kim, Prettina Lazar, Chul Wook Kim, Jeong Dong Bahk, Keun Woo Lee   +6 more
doaj   +1 more source

Prediction of GTP interacting residues, dipeptides and tripeptides in a protein from its evolutionary information

BMC Bioinformatics, 2010
Background Guanosine triphosphate (GTP)-binding proteins play an important role in regulation of G-protein. Thus prediction of GTP interacting residues in a protein is one of the major challenges in the field of the computational biology.
Raghava Gajendra PS, Mishra Nitish K, Chauhan Jagat S   +2 more
doaj   +1 more source

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity

mBio
Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of ...
Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang   +9 more
doaj   +1 more source

Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer.

PLoS ONE, 2017
Green tea polyphenol (GTP) suppresses carcinogenesis and aggressiveness in many types of malignancies including bladder cancer. However, the mechanistic basis of these effects is not well understood.
Tomohiro Matsuo, Yasuyoshi Miyata, Akihiro Asai, Yuji Sagara, Bungo Furusato, Junya Fukuoka, Hideki Sakai   +6 more
doaj   +1 more source

Going in GTP cycles in the nucleolus [PDF]

The Journal of Cell Biology, 2005
Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways.
openaire   +2 more sources

Extracellular GTP is a Potent Water-Transport Regulator via Aquaporin 5 Plasma-Membrane Insertion in M1-CCD Epithelial Cortical Collecting Duct Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: Extracellular GTP is able to modulate some specific functions in neuron, glia and muscle cell models as it has been demonstrated over the last two decades.
Rosa Mancinelli, Rita Maria Laura La Rovere, Stefania Fulle, Sebastiano Miscia, Marco Marchisio, Laura Pierdomenico, Paola Lanuti, Giuseppe Procino, Claudia Barbieri, Maria Svelto, Giorgio Fanò-Illic, Tiziana Pietrangelo   +11 more
doaj   +1 more source

Mechanical properties and durability of recycled gold tail powder concrete

Results in Engineering
Gold tailings powder (GTP) is an industrial waste that is difficult to dispose of, and its accumulation has increasingly severe environmental consequences.
Mingxin Wang, Wenjie Zhao, Hongyi Xi, Teng Zhang, Ziyi Wang   +4 more
doaj   +1 more source

Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1.

PLoS ONE, 2015
The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation.
Glenn Hauk, Gregory D Bowman
doaj   +1 more source

Molecular mechanism for recognition of the cargo adapter Rab6 GTP by the dynein adapter BicD2

Life Science Alliance
We present a structural model for recognition of a key modulator of protein secretion, Rab6 GTP , by the dynein adapter BicD2, which provides new insights into the trafficking of secretory vesicles. Rab6 is a key modulator of protein secretion.
Xiaoxin Zhao, Sebastian Quintremil, Estrella D Rodriguez Castro, Heying Cui, David Moraga, Tingyao Wang, Richard B Vallee, Sozanne R Solmaz   +7 more
doaj   +1 more source

A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs

Cell Reports
Summary: By modulating integrin affinity, the GTP/GDP status of Rap1 affects the arrest, transendothelial migration, and the trafficking of lymphocytes, yet how chemoattractant receptors control Rap1 remains incompletely resolved.
Chung Park, Il-Young Hwang, Kathleen Harrison, Ning-Na Huang, Margery Smelkinson, Sundar Ganesan, Han G. Kim, Pamela L. Schwartzberg, John H. Kehrl   +8 more
doaj   +1 more source