Results 51 to 60 of about 339,556 (339)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Dietary green tea powder supplementation enriched egg nutrients and physicochemical property in an indigenous chicken breed

Poultry Science, 2021
Dietary supplementation of green tea changes the antioxidative capacity of chickens. However, the effect of green tea supplementation in the diet on egg quality and the consequent change in processing capacity is still not well known.
Xingyong Chen, Tao Li, Kaiqin He, Zhaoyu Geng, Xiaochun Wan   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

GTP Binding Assays in Arabidopsis thaliana

Bio-Protocol, 2013
Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
doaj   +1 more source

Structural insights into the mechanism of GTP initiation of microtubule assembly

Nature Communications, 2023
In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is still unknown.
Ju Zhou, Anhui Wang, Yinlong Song, Nan Liu, Jia Wang, Yan Li, Xin Liang, Guohui Li, Huiying Chu, Hong-Wei Wang   +9 more
doaj   +1 more source

A model of membrane contraction predicting initiation and completion of bacterial cell division [PDF]

, 2013
Bacterial cell division involves a complex and dynamic sequence of events whereby polymers of the protein FtsZ assemble at the division plane and rearrange to achieve the goal of contracting the cell membrane at the site of cell division, thus dividing ...
Alison Rodger, Anderson, Astumian, Astumian, Beuria, Bi, Bramhill, Bramhill, Caplan, Chen, Chen, Chen, Claire E. Dow, Corbin, Culbertson, David I. Roper, de Boer, Den Blaauwen, Erickson, Erickson, Feucht, Hale, Haney, Huecas, Hugo A. van den Berg, Hörger, Hörger, Lan, Li, Liu, Lu, Lu, Lutkenhaus, Löwe, Margolin, Martos, Mateos-Gil, Maupin, Mingorance, Mukherjee, Mukherjee, Oliva, Osawa, Pacheco-Gómez, Pichoff, Pla, RayChaudhuri, Romberg, Romberg, Rueda, Scheffers, Scheffers, Schmidt, Small, Stricker, Sun, Surovtsev, Surovtsev, Taschner, Turner   +59 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Characterization of geothermal resources and estimation of power potential of Badrinath geothermal field northwest Himalaya India

Scientific Reports
Geothermal energy is a recognized renewable resource in the present scenario, with over 30 nations generating electricity and 88 using it for heating and heat pumps.
Sameer K. Tiwari, Árni Ragnarsson, Gudni Axelsson   +2 more
doaj   +1 more source

Persistent activation of transducin by bleached rhodopsin in salamander rods. [PDF]

, 1996
The hydrolysis-resistant GTP analogue GTP-gamma-S was introduced into rods isolated from the retina of the salamander Ambystoma tigrinum to study the origin of the persistent excitation induced by intense bleaching illumination.
Cornwall, MC, Fain, GL, Matthews, HR
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source