Results 61 to 70 of about 517 (97)

Signalling mechanisms used by the orexin-1 receptor [PDF]

Peltonen, Hanna
core  

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. [PDF]

Nat Commun
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG.   +19 more
europepmc   +1 more source

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. [PDF]

Nat Chem Biol, 2020
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA.   +11 more
europepmc   +1 more source

Identification of Gα₁₂-vs-Gα₁₃-coupling determinants and development of a Gα_12/13-coupled designer GPCR. [PDF]

Sci Rep
Tatsumi M, Cruz C, Kamakura N, Kuwabara R, Nakamura G, Ikuta T, Abrol R, Inoue A.   +7 more
europepmc   +1 more source

Gα12 and Gα13 proteins are required for transforming growth factor-β-induced myofibroblast differentiation. [PDF]

Biochem J
Reed EB, Sitikov A, Shin KWD, Hamanaka RB, Cetin-Atalay R, Mutlu GM, Mongin AA, Dulin NO.   +7 more
europepmc   +1 more source

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor. [PDF]

Nat Commun
Li X, Winters ND, Pandey S, Lankford C, Stoveken HM, Smith E, Chang CT, Zucca S, Scampavia L, Spicer T, Martemyanov KA.   +10 more
europepmc   +1 more source

The PAR2 inhibitor I-287 selectively targets Gα_q and Gα_12/13 signaling and has anti-inflammatory effects. [PDF]

Commun Biol, 2020
Avet C, Sturino C, Grastilleur S, Gouill CL, Semache M, Gross F, Gendron L, Bennani Y, Mancini JA, Sayegh CE, Bouvier M.   +10 more
europepmc   +1 more source

GNA13 suppresses proliferation of ER+ breast cancer cells via ERα dependent upregulation of the MYC oncogene. [PDF]

Breast Cancer Res
Subramanyan LV, Rasheed SAK, Wang L, Ghosh S, Ong MSN, Lakshmanan M, Wang M, Casey PJ.   +7 more
europepmc   +1 more source

GPCR-Gα13 Involvement in Mitochondrial Function, Oxidative Stress, and Prostate Cancer. [PDF]

Int J Mol Sci
Wu D, Casey PJ.
europepmc   +1 more source

GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer models and interface interactions. [PDF]

Nucleic Acids Res
Pándy-Szekeres G, Taracena Herrera LP, Caroli J, Kermani AA, Kulkarni Y, Keserű GM, Gloriam DE.   +6 more
europepmc   +1 more source