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Regulation of phagocyte function by low molecular weight GTP‐binding proteins [PDF]
European Journal of Haematology, 1993 Abstract: The mechanisms used by phagocytic leukocytes in the process of bacterial killing are regulated by GTP‐binding proteins of the Ras superfamily. In particular, the formation of toxic oxygen metabolites via the NADPH oxidase requires the action of both Rac and Rap1A proteins.
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Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
Plant Physiology, 2023Heterotrimeric GTP-binding proteins (G proteins) are a group of regulators essential for signal transmission into cells. Regulator of G-protein signaling 1 (AtRGS1) possesses intrinsic GTPase-accelerating protein (GAP) activity and could suppress G ...
Qian Yu +9 more
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Distribution and Regulation of RAB3C, a Small Molecular Weight GTP-Binding Protein
Biochemical and Biophysical Research Communications, 1994We have investigated the expression and regulation of rab3C in rat tissues and rat pheochromocytoma PC12 cells by using a polyclonal antibody that specifically recognizes this protein. Rab3C was expressed in the neuroendocrine systems, as is its highly homologous family member, rab3A.
Lung-Sen Kao +5 more
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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Journal of Microscopy, 2008SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
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Cellular responses regulated by rho-related small GTP-binding proteins
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
Peter Adamson +3 more
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The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast Function
Calcified Tissue International, 2003The Ras superfamily of small GTP-binding proteins (also known as small GTPases) comprises more than 80 highly conserved proteins of the Ras, Rho, and Rab subfamilies that are involved in multiple intracellular signalling pathways. These proteins are able to function as molecular switches in the transduction of signals from membrane receptors by cycling
Michael J. Rogers, Fraser P. Coxon
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The regulation of mitochondrial physiology by organelle‐associated GTP‐binding proteins
Cell Biochemistry and Function, 2002AbstractRecent studies have shown that GTP‐binding proteins can modulate mitochondrial membrane fusion and fission. Furthermore, GTP‐binding proteins can regulate the binding of ribosomes to the mitochondrial membrane and may facilitate the import of proteins through contact points between inner and outer mitochondrial membranes.
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Regulation of phospholipase D by low molecular weight GTP-binding proteins
Journal of Lipid Mediators and Cell Signalling, 1996Phospholipase D (PLD) is believed to play an important role in cell signal transduction: PLD catalyzes the hydrolysis primarily of phosphatidylcholine (PC) to produce phosphatidic acid that may serve as a lipid second messenger. Although the mechanism of PLD activation has not yet been fully understood, a member of the low molecular weight GTP-binding ...
Yasunori Kanaho +2 more
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Regulation of the phagocyte respiratory burst by small GTP-binding proteins
Trends in Cell Biology, 1995Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
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Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins
Current Opinion in Cell Biology, 1994Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the
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