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Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery

Ras Superfamily Small G Proteins: Biology and Mechanisms 2, 2014
The Arf small GTP-binding (G) proteins regulate membrane traffic and organelle structure in eukaryotic cells through a regulated cycle of GTP binding and hydrolysis.
C. L. Jackson
semanticscholar   +1 more source

Rab3 Small GTP—Binding Proteins: Regulation by Calcium/Calmodulin

2003
Rab proteins, forming a subfamily of 52 predominantly membrane-bound, low molecular weight GTP-binding proteins (G-proteins) of the Ras superfamily, are involved in vesicle traffic between intracellular organelles, endocytosis and exocytosis, and may be regulated by calcium (Ca2 +) and/or calmodulin (CaM).
Richard R. Clough   +2 more
openaire   +2 more sources

Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss

American Journal of Physiology-Endocrinology and Metabolism, 2013
The developmentally regulated GTP-binding protein-2 (DRG2) is a novel subclass of GTP-binding proteins. Many functional characteristics of osteoclasts (OC) are associated with small GTPases. We hypothesized that DRG2 affects bone mass via modulating OC activity. Using DRG2 transgenic mice, we investigated the role of DRG2 in bone remodeling.
Hye-Seon Choi   +9 more
openaire   +3 more sources

Regulation of G protein-coupled receptor endocytosis by ARF6 GTP-binding proteins

Biochemistry and Cell Biology, 2004
The function of G protein-coupled receptors is regulated by a broad variety of membrane-bound and intracellular proteins. These act in concert to activate signaling pathways that will lead to the desensitization of activated receptors and, for most receptor types, their trafficking to intracellular compartments.
openaire   +3 more sources

Study of Rab6, a Ras‐like GTP‐binding Protein Associated with the Golgi Complex

Annals of the New York Academy of Sciences, 1994
B. Goud   +4 more
semanticscholar   +2 more sources

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

Current Opinion in Cell Biology, 1996
Integrin signalling requires the activation of protein tyrosine kinases and members of the Rho family of small GTP-binding proteins. Recent evidence shows that coordinated regulation of these signalling molecules is central to the control of cell adhesion, formation of the actin cytoskeleton and activation of intracellular signalling cascades.
openaire   +2 more sources

The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm

Molecular Reproduction and Development, 1999
C. Ward, D. Faundes, J. Foster
semanticscholar   +1 more source

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