Results 291 to 300 of about 154,453 (348)

Regulation of rod GTP binding protein by guanine nucleotides.

Journal of biochemistry, 1985
The rod GTP-binding protein in the bovine disk membrane seems to exist as oligomers in the dark. G alpha and G beta do not interact strongly, and G gamma may be required for G alpha . GDP to dimerize.
H, Shichi, R L, Somers
openaire   +1 more source

The GTP-binding protein, Go, regulates neuronal calcium channels.

Nature, 1987
In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has yet been demonstrated.
J, Hescheler, W, Rosenthal, W, Trautwein, G, Schultz   +3 more
openaire   +1 more source

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

Trends in Cell Biology, 1995
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
openaire   +2 more sources

Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins

Journal of Microscopy, 2008
SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
openaire   +2 more sources

Loss of the conserved switch III region in a G protein leads to severe pediatric encephalopathy.

Science Signaling
The α subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) in G protein-coupled receptor (GPCR) pathways operate as gate switches by cycling through inactive GDP-bound and active GTP-bound states. Three flexible regions (switches I
Mikhail Savitsky, Y. Larasati, Gonzalo P. Solis, A. Koval, Ana Camacho, Noemí Núñez, O. Patat, Elisabeth Wallach, S. Galosi, M. Novelli, Simone Martinelli, Vincenzo Leuzzi, Vladimir L. Katanaev   +12 more
semanticscholar   +1 more source

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

Current Opinion in Cell Biology, 1996
Integrin signalling requires the activation of protein tyrosine kinases and members of the Rho family of small GTP-binding proteins. Recent evidence shows that coordinated regulation of these signalling molecules is central to the control of cell adhesion, formation of the actin cytoskeleton and activation of intracellular signalling cascades.
openaire   +2 more sources

Rab32 regulates Golgi structure and cell migration through Protein Kinase A–mediated phosphorylation of Optineurin

Proceedings of the National Academy of Sciences of the United States of America
Significance Golgi assembly and dynamics during cell migration are tightly controlled by signaling and cytoskeletal regulators, resulting in polarized Golgi distribution that supports directional migration.
Katherine M. Johnson, Maxwell G Marley, Kristina Drizyte-Miller, Jing Chen, H. Cao, Nourhan Mostafa, Micah B. Schott, M. McNiven, G. Razidlo   +8 more
semanticscholar   +1 more source

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

Nature, 1991
G. F. V. Mollard, T. Südhof, R. Jahn
semanticscholar   +1 more source

Activation of a small GTP-binding protein by nucleoside diphosphate kinase.

Science, 1991
P. Randazzo, J. Northup, R. A. Kahn
semanticscholar   +1 more source

Study of Rab6, a Ras‐like GTP‐binding Protein Associated with the Golgi Complex

Annals of the New York Academy of Sciences, 1994
B. Goud, Chunzhi Yang, M. Roa, Olivier Martinez, V. Slepnev   +4 more
semanticscholar   +2 more sources