Results 1 to 10 of about 54,616 (146)

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]

BMB Reports, 2011
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi, Malys, Naglis, Mendes, Pedro, Smallbone, Kieran   +3 more
core   +3 more sources

Identification of genes encoding zinc finger proteins, non-histone chromosomal HMG protein homologue, and a putative GTP phosphohydrolase in the genome of Chilo iridescent virus

Nucleic Acids Research, 1994
Five RNA transcripts of about 1.2 to 1.7 kilobases were mapped to a part of the genome of insect iridescent virus type 6 (Chilo iridescent virus; CIV) between genome coordinates 0.832 and 0.856 within the EcoRI DNA fragment F. The nucleotide sequence of this particular region (5702 base pairs) of the CIV genome was determined. The DNA sequence contains
Paul Schnitzler, Michael Hug, Michaela Handermann, Waltraud Janssen, Eugene V. Koonin, Hajo Delius, Gholamreza Darai   +6 more
openalex   +5 more sources

Heterozygous OPA1 mutations in Behr syndrome [PDF]

, 2010
International ...
A. Brice, A. Dürr, A. Layet, C. Marelli, D. Bonneau, E. Brissaud, G. Stevanin, P. Amati-Bonneau, P. Reynier, V. Layet   +9 more
core   +4 more sources

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse [PDF]

, 2012
Dominant optic atrophy is a rare inherited optic nerve degeneration caused by mutations in the mitochondrial fusion gene OPA1. Recently, the clinical spectrum of dominant optic atrophy has been extended to frequent syndromic forms, exhibiting various ...
A.L. Mausset-Bonnefont, B. Chaix, C. Angebault Prouteau, C. Cazevieille, C. Delettre, C. Hamel, E. Sarzi, G. Bielicki, G. Lenaers, J. Wang, J.L. Puel, J.P. Renou, M. Seveno, N. Boddaert, N. Gueguen, P. Brabet, P. Reynier, V. Rigau   +17 more
core   +3 more sources

Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading

Nature, 2020
Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is delivered by the elongation factor EF-Tu 1 . To understand the molecular mechanism of this proofreading step it is necessary to visualize GTP-catalysed elongation, which has ...
A. Loveland, G. Demo, A. Korostelev
semanticscholar   +1 more source

Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae) [PDF]

, 2013
BACKGROUND: The Hunt bumble bee (Bombus huntii Greene, Hymenoptera: Apidae) is a holometabolous, social insect important as a pollinator in natural and agricultural ecosystems in western North America.
Dennis L Welker, James P Strange, Junhuan Xu, Rosalind R James   +3 more
core   +1 more source

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

ACS Central Science, 2020
We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound
Ziyang Zhang, R. Gao, Q. Hu, H. Peacock, D. M. Peacock, Shizhong A. Dai, K. Shokat, H. Suga   +7 more
semanticscholar   +1 more source

Metal Fluorides as Analogs for Studies on Phosphoryl Transfer Enzymes [PDF]

, 2017
The 1994 structure of a transition state analog with AlF4- and GDP complexed to G1, a small G protein, heralded a new field of research into structure and mechanism of enzymes that manipulate transfer of the phosphoryl (PO3-) group.
Admiraal, Anderson, Antony, Batsanov, Baur, Baxter, Baxter, Baxter, Baxter, Berente, Bigay, Blackburn, Blackburn, Bock, Boone, Bowler, Bruice, Brunk, Burgos, Cavalli, Cleland, Cliff, Coleman, Du, Field, Fisher, Fovet, Frey, Geerlings, Graham, Graham, Griffin, Grigorenko, Grigorenko, Hemsworth, Henry, Higashijima, Hilbert, Himo, Hoffman, Hur, Issartel, Jackson, Jin, Jin, Jin, Kamerlin, Khrenova, Klink, Klähn, Knowles, Kowalinski, Lahiri, Lassila, Leigh, Lienhard, Liu, Lowe, Madhusudan, Maegley, Marcos, Martin, Martin, Maruta, Mesmer, Mildvan, Oldfield, Park, Pauling, Plotnikov, Praefcke, Prasad, Pylypenko, Pérez-Gallegos, Pérez-Gallegos, Ribeiro, Rittinger, Scheffzek, Schlichting, Schlichting, Senn, Sheftic, Shinoda, Shurki, Siegbahn, Smith, Sondek, Sośnicki, Sternweis, Thorsell, Topol, Toyoshima, Valiev, Wang, Warshel, Webster, Wolfenden, Zhang   +97 more
core   +5 more sources

Systematic Production of Inactivating and NonInactivating Suppressor Mutations at the relA Locus That Compensate the Detrimental Effects of Complete spoT Loss and Affect Glycogen Content in Escherichia coli [PDF]

, 2014
In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function hydrolase/synthetase SpoT.
Almagro, Goizeder, Bahaji, Abdellatif, Bernal, Cristina, Bora Fernandez, Edurne, Canovas, Manuel, Codoñer, Francisco M., Eydallin, Gustavo, Lozano, Ana Belen, Montero, Manuel, Mori, Hirotada, Muñoz, Francisco Jose, Potueza Romeo, Javier, Rahimpour, Mehdi, Sevilla, Angel, Viale, Alejandro Miguel   +14 more
core   +9 more sources

Essential Roles for Mycobacterium tuberculosis Rel beyond the Production of (p)ppGpp [PDF]

, 2013
In Mycobacterium tuberculosis, the stringent response to amino acid starvation is mediated by the M. tuberculosis Rel (Rel(Mtb)) enzyme, which transfers a pyrophosphate from ATP to GDP or GTP to synthesize ppGpp and pppGpp, respectively.
Stallings, Christina L., Weiss, Leslie A.   +1 more
core   +2 more sources