Results 11 to 20 of about 54,635 (165)
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes
British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +28 more
wiley +1 more source
New Phytologist, Volume 239, Issue 1, Page 222-239, July 2023., 2023 Summary To infect plants, pathogenic fungi secrete small proteins called effectors. Here, we describe the catalytic activity and potential virulence function of the Nudix hydrolase effector AvrM14 from the flax rust fungus (Melampsora lini). We completed extensive in vitro assays to characterise the enzymatic activity of the AvrM14 effector ...
Carl L. McCombe +11 more
wiley +1 more source
Targeting the DNA damage response and repair in cancer through nucleotide metabolism
Molecular Oncology, Volume 16, Issue 21, Page 3792-3810, November 2022., 2022 The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of the DNA molecule are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are produced and maintained by nucleotide metabolic pathways.
Thomas Helleday, Sean G. Rudd
wiley +1 more source
Physiologic roles of P2 receptors in leukocytes
Journal of Leukocyte Biology, Volume 112, Issue 5, Page 983-1012, November 2022., 2022 Graphical Abstract Review of how purinergic P2 receptors expression and activation in leukocytes control the development of inflammation, infectious diseases, and pain. Abstract Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types.
Anael Viana Pinto Alberto +10 more
wiley +1 more source
Noncanonical metabolite RNA caps: Classification, quantification, (de)capping, and function
WIREs RNA, Volume 13, Issue 6, November/December 2022., 2022 Metabolite caps are distinct 5′‐terminal modifications of RNA that occur in prokaryotes and eukaryotes. Abundant metabolites such as NAD, CoA, or NpnNs serve as noncanonical initiating nucleotides during transcription. Turnover, stability, and function are tightly regulated for specific subgroups of metabolite‐capped RNAs.
Johanna Mattay
wiley +1 more source
Protein Science, Volume 31, Issue 9, September 2022., 2022 Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders +4 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes
British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +32 more
wiley +1 more source
Angewandte Chemie, 2020 KRAS homo-dimerization has been implicated in the activation of RAF kinases, however, the mechanism and structural basis remain elusive. We developed a system to study KRAS dimerization on nanodiscs using paramagnetic relaxation enhancement (PRE) NMR ...
Ki‐Young Lee +7 more
semanticscholar +1 more source
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
ACS Central Science, 2019 Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes and tumor suppression.
Vanessa A N Kraft +16 more
semanticscholar +1 more source
eLife, 2020 We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP.
Anna Plana-Bonamaisó +13 more
semanticscholar +1 more source