Results 11 to 20 of about 5,029 (135)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways

New Phytologist, Volume 239, Issue 1, Page 222-239, July 2023., 2023
Summary To infect plants, pathogenic fungi secrete small proteins called effectors. Here, we describe the catalytic activity and potential virulence function of the Nudix hydrolase effector AvrM14 from the flax rust fungus (Melampsora lini). We completed extensive in vitro assays to characterise the enzymatic activity of the AvrM14 effector ...
Carl L. McCombe, Ann‐Maree Catanzariti, Julian R. Greenwood, Anna M. Desai, Megan A. Outram, Daniel S. Yu, Daniel J. Ericsson, Steven E. Brenner, Peter N. Dodds, Bostjan Kobe, David A. Jones, Simon J. Williams   +11 more
wiley   +1 more source

Targeting the DNA damage response and repair in cancer through nucleotide metabolism

Molecular Oncology, Volume 16, Issue 21, Page 3792-3810, November 2022., 2022
The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of the DNA molecule are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are produced and maintained by nucleotide metabolic pathways.
Thomas Helleday, Sean G. Rudd
wiley   +1 more source

Physiologic roles of P2 receptors in leukocytes

Journal of Leukocyte Biology, Volume 112, Issue 5, Page 983-1012, November 2022., 2022
Graphical Abstract Review of how purinergic P2 receptors expression and activation in leukocytes control the development of inflammation, infectious diseases, and pain. Abstract Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types.
Anael Viana Pinto Alberto, Natiele Carla da Silva Ferreira, André Gustavo Calvano Bonavita, Oscar Kenji Nihei, Fernando Pires de Farias, Rodrigo da Cunha Bisaggio, Cristóvão de Albuquerque, Wilson Savino, Robson Coutinho‐Silva, Pedro Muanis Persechini, Luiz Anastacio Alves   +10 more
wiley   +1 more source

Noncanonical metabolite RNA caps: Classification, quantification, (de)capping, and function

WIREs RNA, Volume 13, Issue 6, November/December 2022., 2022
Metabolite caps are distinct 5′‐terminal modifications of RNA that occur in prokaryotes and eukaryotes. Abundant metabolites such as NAD, CoA, or NpnNs serve as noncanonical initiating nucleotides during transcription. Turnover, stability, and function are tightly regulated for specific subgroups of metabolite‐capped RNAs.
Johanna Mattay
wiley   +1 more source

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Identification of genes encoding zinc finger proteins, non-histone chromosomal HMG protein homologue, and a putative GTP phosphohydrolase in the genome of Chilo iridescent virus

Nucleic Acids Research, 1994
Five RNA transcripts of about 1.2 to 1.7 kilobases were mapped to a part of the genome of insect iridescent virus type 6 (Chilo iridescent virus; CIV) between genome coordinates 0.832 and 0.856 within the EcoRI DNA fragment F. The nucleotide sequence of this particular region (5702 base pairs) of the CIV genome was determined. The DNA sequence contains
P, Schnitzler, M, Hug, M, Handermann, W, Janssen, E V, Koonin, H, Delius, C, Darai   +6 more
openaire   +3 more sources

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]

, 2011
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi, Malys, Naglis, Mendes, Pedro, Smallbone, Kieran   +3 more
core   +2 more sources

Heterozygous OPA1 mutations in Behr syndrome [PDF]

, 2010
International ...
A. Brice, A. Dürr, A. Layet, C. Marelli, D. Bonneau, E. Brissaud, G. Stevanin, P. Amati-Bonneau, P. Reynier, V. Layet   +9 more
core   +4 more sources