Results 41 to 50 of about 54,635 (165)
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
NatureBroad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations1,2.
Urszula N. Wasko +65 more
semanticscholar +1 more source
GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases.
Journal of the American Chemical Society, 2019 GTP hydrolysis is a biologically crucial reaction, being involved in regulating almost all cellular processes. As a result the enzymes that catalyze this reaction are amongst the most important drug targets.
A. R. Calixto +6 more
semanticscholar +1 more source
Metabolic Origin, Role and Fate of the Denaturant Guanidine
Microbial Biotechnology, Volume 18, Issue 11, November 2025.The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin +3 more
wiley +1 more source
Neural Plasticity, Volume 2015, Issue 1, 2015., 2015 In a phase I/IIa open‐label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI).
Ji Cheol Shin +12 more
wiley +1 more source
, 2016 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Filloux, A, Valentini, M
core +2 more sources
MedComm, Volume 6, Issue 3, March 2025.The malignant transformation from chronic viral hepatitis to hepatocellular carcinoma (HCC) involves intricate interactions among viral, host, and environmental factors. Key drivers of this transformation include viral integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, chronic inflammation, immune ...
Huimin Yuan +6 more
wiley +1 more source
Specific Proteins in Nontuberculous Mycobacteria: New Potential Tools
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Nontuberculous mycobacteria (NTM) have been isolated from water, soil, air, food, protozoa, plants, animals, and humans. Although most NTM are saprophytes, approximately one‐third of NTM have been associated with human diseases. In this study, we did a comparative proteomic analysis among five NTM strains isolated from several sources.
Patricia Orduña +5 more
wiley +1 more source
Restricted Access to Myeloid Cells Explained [PDF]
, 2011 The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular
Planelles, Vicente
core +3 more sources
Photoreceptor phosphodiesterase (PDE6): structure, regulatory mechanisms, and implications for treatment of retinal diseases [PDF]
, 2021 The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases responsible for hydrolyzing the second messengers cAMP and cGMP.
Cote, Rick H +3 more
core +2 more sources
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Science, 2018 Severing to build microtubules Microtubules are essential intracellular polymers, built from tubulin subunits, that establish cell shape, move organelles, and segregate chromosomes during cell division. Vemu et al.
Annapurna Vemu +6 more
semanticscholar +1 more source