Results 41 to 50 of about 5,029 (135)
Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 T. pallidum, the syphilis‐causing pathogen, performs very differently in metabolism compared with other bacterial pathogens. The desire for safe and effective vaccine of syphilis requests identification of important steps in T. pallidum’s metabolism. Here, we apply Flux Balance Analysis to represent the reactions quantitatively. Thus, it is possible to
Xueying Chen +3 more
wiley +1 more source
, 2016 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Filloux, A, Valentini, M
core +2 more sources
Secretory pathway of trypanosomatid parasites [PDF]
, 2002 The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J. +3 more
core +1 more source
Metabolic Origin, Role and Fate of the Denaturant Guanidine
Microbial Biotechnology, Volume 18, Issue 11, November 2025.The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin +3 more
wiley +1 more source
Neural Plasticity, Volume 2015, Issue 1, 2015., 2015 In a phase I/IIa open‐label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI).
Ji Cheol Shin +12 more
wiley +1 more source
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing [PDF]
, 2013 BACKGROUND: The major role of enzymatic toxins that target nucleic acids in biological conflicts at all levels has become increasingly apparent thanks in large part to the advances of comparative genomics.
A Maxwell Burroughs +4 more
core +1 more source
MedComm, Volume 6, Issue 3, March 2025.The malignant transformation from chronic viral hepatitis to hepatocellular carcinoma (HCC) involves intricate interactions among viral, host, and environmental factors. Key drivers of this transformation include viral integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, chronic inflammation, immune ...
Huimin Yuan +6 more
wiley +1 more source
Specific Proteins in Nontuberculous Mycobacteria: New Potential Tools
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Nontuberculous mycobacteria (NTM) have been isolated from water, soil, air, food, protozoa, plants, animals, and humans. Although most NTM are saprophytes, approximately one‐third of NTM have been associated with human diseases. In this study, we did a comparative proteomic analysis among five NTM strains isolated from several sources.
Patricia Orduña +5 more
wiley +1 more source
A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders [PDF]
, 2018 Purpose: Dominant optic atrophy (DOA; MIM [Mendelian Inheritance in Man] 165500), resulting in retinal ganglion cell degeneration, is mainly caused by mutations in the optic atrophy 1 (OPA1) gene, which encodes a dynamin guanosine triphosphate (GTP)ase ...
A. Chevrollier +16 more
core +2 more sources
Ecto-enzymes of mammary gland and its tumours. Ca2+- or Mg2+-stimulated adenosine triphosphatase and its perturbation by concanavalin A [PDF]
, 1980 Intact viable 13762 mammary-adenocarcinoma ascites cells hydrolyse added ATP. The localization of hydrolysis product and inactivation by the slowly penetrating chemical reagent diazotized sulphanilic acid indicate that this ATPase is at the external ...
C A C Carraway +3 more
core +1 more source