Results 151 to 160 of about 1,798,469 (249)

Avl9 defines a family of DENN domain GTPase-activating proteins. [PDF]

J Cell Biol
Vignogna RC, Fromme JC.
europepmc   +1 more source

Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia

Biotechnology Progress, EarlyView.
Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng, Huajian Chen, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +6 more
wiley   +1 more source

<i>De novo</i> mutation in the <i>ARHGAP32</i> gene endorses the implication of GTPase-activating proteins (RhoGAP family) in idiopathic autism spectrum disorder. [PDF]

Front Psychiatry
Cirnigliaro L, Saccuzzo L, Marzà V, Randazzo M, Perdichizzi M, Romano C, Fichera M, Rizzo R, Barone R.   +8 more
europepmc   +1 more source

Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions. [PDF]

Cold Spring Harb Perspect Med, 2019
Scheffzek K, Shivalingaiah G.
europepmc   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

A Systematic Analysis of Expression and Function of RAS GTPase-Activating Proteins (RASGAPs) in Urological Cancers: A Mini-Review. [PDF]

Cancers (Basel)
Song H, Wang G, Gao G, Xia H, Jiao L, Wu K.   +5 more
europepmc   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. [PDF]

Sci Rep, 2019
Xie Y, Mansouri M, Rizk A, Berger P.
europepmc   +1 more source

Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C. [PDF]

Cancer Cell Int
Sulimenko V, Dráberová E, Sládková V, Sulimenko T, Vosecká V, Skalli O, Dráber P.   +6 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source