Results 1 to 10 of about 42,798 (278)
Rho GTPases in Model Systems [PDF]
Cells, 2023 Since the discovery of their role in the regulation of actin cytoskeleton 30 years ago, Rho GTPases have taken center stage in cell motility research [...]
Vedrana Filić, Igor Weber
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Delta-Catenin as a Modulator of Rho GTPases in Neurons [PDF]
Frontiers in Cellular Neuroscience, 2022 Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta +5 more
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The potential therapeutic roles of Rho GTPases in substance dependence [PDF]
Frontiers in Molecular Neuroscience, 2023 Rho GTPases family are considered to be molecular switches that regulate various cellular processes, including cytoskeleton remodeling, cell polarity, synaptic development and maintenance.
Qin Ru +4 more
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Dahuang—Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases [PDF]
Frontiers in Pharmacology, 2023 Introduction: Dahuang-Taoren (DT) is a classic combination of botanical drugs applied to treat pain-related diseases in ancient China. Today, DT is frequently applied for dysmenorrhea of adenomyosis (AM) in the clinic.
Ya Lei +7 more
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Role of Rho GTPases in inflammatory bowel disease [PDF]
Cell Death Discovery, 2023 Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as “molecular switch” in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD).
Xiaoling Li +8 more
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Structural Dynamics of Rho GTPases. [PDF]
J Mol BiolRho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular processes. While the detailed understanding of Ras structure and function has led to tremendous progress in oncogenic Ras-targeted drug discovery, studies of the related Rho GTPases are still catching up as the recurrent cancer-related Rho GTPase mutations ...
Lin Y, Zheng Y.
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Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses
Cells, 2020 Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin cytoskeleton. They were originally thought to primarily affect cell migration and invasion; however, recent advances in our understanding of the biology and function of ...
Brock Humphries +2 more
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Rho-GTPases subfamily: cellular defectors orchestrating viral infection [PDF]
Cellular & Molecular Biology LettersRas homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical processes such as viral entry, replication ...
Beibei Zhang +5 more
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The Multiple Functions of Rho GTPases in Fission Yeasts [PDF]
Cells, 2021 The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the ...
Jero Vicente-Soler +4 more
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Role of Rho-GTPases in megakaryopoiesis. [PDF]
Small GTPases, 2021 Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called proplatelets, through the endothelial barrier to allow platelet release into blood.
Vainchenker W +5 more
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