Cells, 2020 The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
Daji Guo, Xiaoman Yang
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RHO GTPase family in hepatocellular carcinoma [PDF]
Experimental Hematology & Oncology, 2022 RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular ...
Tiantian Wang +6 more
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The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning [PDF]
The EMBO JournalRho GTPases form plasma membrane-associated patterns that control the cytoskeleton during cell division, morphogenesis, migration, and wound repair.
Michael C Armstrong +9 more
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In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia [PDF]
Journal of Genetic Engineering and BiotechnologyGiardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole.
Nurhana Jasni +6 more
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Targeting Rho GTPase Signaling Networks in Cancer
Frontiers in Cell and Developmental Biology, 2020 As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression.
Anne Ridley, Ridley Anne J
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Pan-cancer analyses identify oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes [PDF]
Frontiers in BioinformaticsRHO family GTPases are key regulators of cancer-related processes such as cytoskeletal dynamics and cell migration, proliferation, and survival. Despite this, a comprehensive understanding of RHO signaling alterations across tumors is still lacking.
Rubén Fernández +10 more
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A Rho GTPase-effector ensemble governs cell migration behavior [PDF]
Nature CommunicationsHow can a cell navigate its environment without any external cues? Since such cues are not always present in the environment, cells rely on internal machinery to explore their surroundings.
Heeyoung Lee +13 more
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Frontiers in Oncology, 2019 Tumor associated macrophages (TAMs) are increasingly recognized as major contributors to the metastatic progression of breast cancer and enriched levels of TAMs often correlate with poor prognosis.
Joel Yates +2 more
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Adverse clinical outcomes and immunosuppressive microenvironment of RHO-GTPase activation pattern in hepatocellular carcinoma [PDF]
Journal of Translational MedicineBackground Emerging evidence suggests that Rho GTPases play a crucial role in tumorigenesis and metastasis, but their involvement in the tumor microenvironment (TME) and prognosis of hepatocellular carcinoma (HCC) is not well understood.
Qi Yang +11 more
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Fixing the GAP: The role of RhoGAPs in cancer
European Journal of Cell Biology, 2022 Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman +2 more
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