Results 11 to 20 of about 251,198 (269)
The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns [version 1; referees: 2 approved] [PDF]
F1000Research, 2016 Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology.
Rafael Dominik Fritz, Olivier Pertz
doaj +3 more sources
Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling [PDF]
Viruses, 2011 Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies.
Herman W. Favoreel +1 more
doaj +2 more sources
Rho GTPase expression in human myeloid cells. [PDF]
PLoS ONE, 2012 Myeloid cells are critical for innate immunity and the initiation of adaptive immunity. Strict regulation of the adhesive and migratory behavior is essential for proper functioning of these cells.
Suzanne F G van Helden +3 more
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Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]
PLoS ONE, 2013 Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng +10 more
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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2021 Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small GTPase superfamily and play essential roles in a variety of cellular functions.
William Guiler +3 more
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The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis. [PDF]
PLoS ONE, 2015 Rho GTPases are important members of the Ras superfamily, which represents the largest signaling protein family in eukaryotes, and function as key molecular switches in converting and amplifying external signals into cellular responses. Although numerous
Xue Li +10 more
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Rho GTPase signaling in rheumatic diseases
iScience, 2022 Summary: Rho guanosine triphosphatase (GTPases), as molecular switches, have been identified to be dysregulated and involved in the pathogenesis of various rheumatic diseases, mainly including rheumatoid arthritis, osteoarthritis, systemic sclerosis, and
Ruijie Zeng +4 more
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Delta-Catenin as a Modulator of Rho GTPases in Neurons
Frontiers in Cellular Neuroscience, 2022 Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out
Maxsam S. Donta +5 more
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Small GTPases, 2014 Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell migration has been extensively studied and has mainly focused on the hallmark family members Rho, Rac, and Cdc42. Recent technological advances in cell biology, such as Rho-family GTPase activity biosensors, studies in 3D, and unbiased RNAi-based screens, have
Sadok, Amine, Marshall, Chris J
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Spatio-temporal Rho GTPase signaling - where are we now? [PDF]
, 2010 Rho-family GTPases are molecular switches that transmit extracellular cues to intracellular signaling pathways. Their regulation is likely to be highly regulated in space and in time, but most of what is known about Rho-family GTPase signaling has been ...
Pertz, Olivier
core +3 more sources