Smooth muscle contraction by small GTPase Rho [PDF]
, 2002 2002-05Abnormal contraction of vascular smooth muscle contributes to a variety of diseases such as hypertension and vasospasm in coronary and cerebral arteries.
Kawano, Yoji +2 more
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A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects. [PDF]
PLoS Genetics, 2016 Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In
Katherine Stewart +16 more
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Rho Family GTPases in Cancer [PDF]
Cancers, 2021 This Special Issue containing seminal contributions from international experts highlights the current understanding of Rho GTPases in cancer, with an emphasis on recognizing their central importance as critical targets for cancer therapy and for chemosensitization of current therapeutic strategies [...]
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes [PDF]
, 2006 Peer ...
Pokhilko, Alexandra V +5 more
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Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells
Open Biology, 2023 The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an economically
Jun Morishita, Paul Nurse
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Role of Rho-GTPases in megakaryopoiesis [PDF]
Small GTPases, 2021 Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopods, called proplatelets, through the endothelial barrier to allow platelet release into blood.
Vainchenker, William +5 more
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Characterization of the RhoGAP proteins RGA-3 and RGA-4 and the centrosomal protein SAS-5 in the early "Caenorhabditis elegans" embryo [PDF]
, 2007 The Caenorhabditis elegans embryo serves as a great tool to study cell biological processes like polarization and cell divison. The first cell division is unequal and cell polarization is dependant on the Rho GTPase regulated rearrangement of the cell ...
Schmutz, Cornelia
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Computational analysis of Rho GTPase cycling.
PLoS Computational Biology, 2013 The Rho family of GTPases control actin organization during diverse cellular responses (migration, cytokinesis and endocytosis). Although the primary members of this family (RhoA, Rac and Cdc42) have different downstream effects on actin remodeling, the ...
Cibele Vieira Falkenberg, Leslie M Loew
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The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription [PDF]
, 2009 Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Leefa Chong San, I.V. +9 more
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Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry. [PDF]
, 2015 Entry into mitosis is accompanied by profound changes in cortical actomyosin organization. Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process in a model epithelium.
Rosa, André +7 more
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