Results 51 to 60 of about 251,198 (269)
Control of T lymphocyte morphology by the GTPase Rho
BMC Cell Biology, 2003 Background Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.
Caudell Eva G +7 more
doaj +1 more source
Rho GTPases in embryonic development [PDF]
Small GTPases, 2014 In the last decade, several mouse models for RhoA, Rac1, and Cdc42 have emerged and have contributed a great deal to understanding the precise functions of Rho GTPases at early stages of development. This review summarizes our current knowledge of various mouse models of tissue-specific ablation of Cdc42, Rac1, and RhoA with emphasis on early ...
Philippe M, Duquette +1 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Transition to Quorum Sensing in an Agrobacterium Population: A Stochastic Model. [PDF]
, 2005 Understanding of the intracellular molecular machinery that is responsible for the complex collective behavior of multicellular populations is an exigent problem of modern biology.
Zhang, Lian-Hui +23 more
core +2 more sources
Advanced Materials Interfaces, EarlyView.Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung +6 more
wiley +1 more source
Rho GTPases in ameloblast differentiation
Japanese Dental Science Review, 2016 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial-mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied
Keishi Otsu, Hidemitsu Harada
openaire +3 more sources
Rho GTPases and signaling networks [PDF]
Genes & Development, 1997 The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man. The mammalian Rho-like GTPases comprise at least 10 distinct proteins: RhoA, B, C, D, and E; Rac1 and 2; RacE;
L, Van Aelst, C, D'Souza-Schorey
openaire +2 more sources
Advanced Science, EarlyView.In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor +11 more
wiley +1 more source
Control of Local Rho GTPase Crosstalk by Abr [PDF]
, 2011 SummaryBackgroundThe Rho GTPases—Rho, Rac, and Cdc42—regulate the dynamics of F-actin (filamentous actin) and myosin-2 with considerable subcellular precision.
Emily M. Vaughan +7 more
core +1 more source
Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells [PDF]
, 2019 Much of our current knowledge of Rho GTPase networks and the regulation by Rho guanine exchange factors (Rho GEFs) and Rho GTPase activating proteins (Rho GAPs) is based on population-based techniques.
Joachim Goedhart (79979) +1 more
core +3 more sources