Results 1 to 10 of about 56,745 (159)

Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives [PDF]

Biomedicines
Rho GTPases are a group of guanosine triphosphate (GTP)-binding proteins with a relative molecular weight of about 20–30 kD, and 22 different Rho GTPases have been identified in mammalian cells, among which RhoA, Rac1 and Cdc42 are the most well-studied.
Wei Xiong, Daojia Miao, Zongchen Hou, Xiaoping Zhang, Zhiyong Xiong   +4 more
doaj   +2 more sources

Flux Analysis in Process Models via Causality [PDF]

Electronic Proceedings in Theoretical Computer Science, 2010
We present an approach for flux analysis in process algebra models of biological systems. We perceive flux as the flow of resources in stochastic simulations. We resort to an established correspondence between event structures, a broadly recognised model
Ozan Kahramanoğulları
doaj   +4 more sources

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity

Frontiers in Cardiovascular Medicine, 2022
Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
doaj   +1 more source

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla, B Onken, C Banning, C Vanni, Cathryn Weston, DA Hughes, EC Chang, FD Kelly, FO Bendezú, FS Wouters, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, Graham Ladds, H Murakoshi, H Tatebe, H Tu, I Tratner, J Davey, J Davey, J Davey, J Marks, JL Brown, JM Mitchison, Juan Mata, K Hirota, K Kitamura, K Maundrell, K Nakano, K Scheffzek, M Das, M Didmon, M Hachet-Haas, M Hamilton, M Malumbres, M Toya, MD Abramoff, Michael Bond, O Nielsen, P Fantes, P García, P Gideon, P Papadaki, PM Coll, R Egel, S Ottilie, S Sazer, SA Rincón, SR Sprang, T Masuda, TT Maeda, V Jung, V Snell, Wayne Croft, Y Imai, Y Imai   +58 more
core   +11 more sources

Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Acute Medicine & Surgery, 2022
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura   +13 more
doaj   +1 more source

Visualizing the subcellular localization of RHOB-GTP and GTPase-Effector complexes using a split-GFP/nanobody labelling assay

European Journal of Cell Biology, 2023
Small GTPases are highly regulated proteins that control essential signaling pathways through the activity of their effector proteins. Among the RHOA subfamily, RHOB regulates peculiar functions that could be associated with the control of the endocytic ...
Sebastian Castillo, Rémi Gence, Delphine Pagan, Faten Koraïchi, Catherine Bouchenot, Benoit J. Pons, Betty Boëlle, Aurélien Olichon, Isabelle Lajoie-Mazenc, Gilles Favre, Jean-Denis Pédelacq, Stéphanie Cabantous   +11 more
doaj   +1 more source

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases

Frontiers in Cell and Developmental Biology, 2020
Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos, Boris Lavanderos, Ian Silva, Ian Silva, Pablo Cruz, Pablo Cruz, Octavio Orellana-Serradell, Octavio Orellana-Serradell, María Paz Saldías, María Paz Saldías, Oscar Cerda, Oscar Cerda, Oscar Cerda   +12 more
doaj   +1 more source

Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]

PLoS ONE, 2012
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez, Sara E Nichols, Jacqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Barry J Grant   +5 more
doaj   +1 more source

Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. [PDF]

PLoS ONE, 2014
The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer.
Jacob R Manjarrez, Liang Sun, Thomas Prince, Robert L Matts   +3 more
doaj   +1 more source